determine the incidence of intraoperative hypersensitivity events in one U.S. surgical center. The authors concluded that the overall incidence of anaphylaxis was 1 in 4,583 surgeries, whereas that of hypersensitivity was 1 in 677. However, major methodologic issues should be highlighted, and the results must be debated because no conclusion can be effectively drawn from this study. First, the ...

Hypersensitivity to the fruit mango is extremely rare and can exhibit either as immediate or delayed reactions. Since 1939, only 22 patients (10 with immediate type I reactions and 12 with delayed) have been documented with allergy to mango. History of atopy and geographical region may influence the type of reaction. Immediate reactions occurred most often in patients with history of atopy, whi...

Cefepime is a fourth-generation cephalosporin with a broad antimicrobial spectrum and good activity against both gram-positive and gram-negative organisms. We present the case of a 61-year-old man who developed an immediate urticarial reaction after receiving a single dose of cefepime. Skin tests were positive to cefepime and negative to the other beta-lactam antibiotics. Controlled administrat...

753 March 2014 M ASTOCYTOSIS may be associated with the occurrence of perioperative immediate hypersensitivity reactions. Hypersensitivity corresponds to the reproducible signs or symptoms, initiated by exposure to a defined stimulus at a dose tolerated by normal subjects.1 It is generally accepted that immediate reactions may be delayed for up to an hour.2 Two phenotypes of immediate-type hype...

Background Drug desensitization is the induction of temporary clinical unresponsiveness todrug antigens to which patients have presented severe hypersensitivity reactions (HSR). Rapid desensitization in patients suffering immediate hypersensitivity reactions with chemotherapeutic agents and monoclonal antibodies have been widely described and have shown to be successful. Non-immediate hypersens...

In vivo tests may be used for the diagnosis of allergy to iodinated contrast media (ICM); however, the tests do not provide definitive diagnosis and are associated with risks for patients. Diagnoses based on in vitro tests are limited, and there are almost no relevant studies. Herein, the authors examined involvement of allergic reaction from a multilateral standpoint in 39 patients suspected o...