The title compound, C(9)H(12)ClN(4) (+)·Cl(-), is a natural metabolic product of imidacloprid [systematic name: (E)-1-(6-chloro-3-pyridyl-meth-yl)-N-nitro-imidazolidin-2-yl-idene-amine] and was obtained by the reduction of the latter using Fe in HCl. The dihedral angle between the pyridine and imidazole rings is 62.09 (12)°. The crystal structure is stabilized by N-H⋯Cl and C-H⋯Cl inter-actions...

BACKGROUND The derivatives of 2-substituted 4H-3,1-benzoxazin-4-one belong to a significant category of heterocyclic compounds, which have shown a wide spectrum of medical and industrial applications. RESULTS A new and effective one-pot method for the synthesis of 2-substituted 4H-3,1-benzoxazin-4-one derivatives is described in this paper. By using the iminium cation from a mixture of cyanur...

This review describes a synthesis of indole compounds using multifunctional synthons. The multifunctional synthons, trienes and gramines, were respectively synthesized using Pd-catalyzed tandem cyclization/cross-coupling reaction of indolylborate with vinyl bromide, and reaction of indolylcuprate with iminium chloride. As an application of the multifunctional synthons to the indole alkaloids sy...

The crystal and mol-ecular structures of the title salt, C8H8N3S2 (+)·Cl(-), (I), and salt hydrate, C8H7ClN3S2 (+)·Cl(-)·H2O, (II), are described. The heterocyclic ring in (I) is statistically planar and forms a dihedral angle of 9.05 (12)° with the pendant phenyl ring. The comparable angle in (II) is 15.60 (12)°, indicating a greater twist in this cation. An evaluation of the bond lengths in t...

Compound 1 is a p38 MAP kinase inhibitor potentially useful for the treatment of rheumatoid arthritis and psoriasis. A novel six-step synthesis suitable for large-scale preparation was developed in support of a drug development program at Merck Research Laboratories. The key steps include a tandem Heck-lactamization, N-oxidation, and a highly chemoselective Grignard addition of 4-(N-tert-butylp...

Triflic anhydride (Tf2O) is the reagent of choice for the introduction of the trifluoromethylsulfonyl (CF3SO2) group into a variety of organic substrates, and the resulting compounds often have a unique chemical reactivity [1]. A case in point is given by 3-trifloxypropene iminium triflates which are obtained by O-sulfonylation of enaminones with Tf2O [2, 3] and which are suited for transformat...

A series of amino derivative of 1-indene and 9-fluorene have been synthesized from their corresponding iminium salt, generated in situ in the concentrated ethereal lithium perchlorate solution, and 1-indenyl or 9-fluorenyl anions. The yields of the reactions depend on the kind of anion. Addition of 1-indeny anion to the iminium salt gives the amino derivative of 1-indene, while addition of fluo...

Sanguinarine (SANG), a key member of the benzylisoquinoline alkaloid family, is well-known for its various therapeutic applications such as antimicrobial, antitumor, anticancer, antifungal and anti-inflammatory etc. Depending on the medium pH, SANG exists in the iminium or alkanolamine form, which emits at 580 nm and 420 nm, respectively. Nucleophilic attack on the C6 carbon atom converts the i...

a series of amino derivative of 1-indene and 9-fluorene have been synthesized from their corresponding iminium salt, generated in situ in the concentrated ethereal lithium perchlorate solution, and 1-indenyl or 9-fluorenyl anions. the yields of the reactions depend on the kind of anion. addition of 1-indeny anion to the iminium salt gives the amino derivative of 1-indene, while addition of fluo...

BACKGROUND Interaction of the iminium and alkanolamine forms of sanguinarine with bovine serum albumin (BSA) was characterized by spectroscopic and calorimetric techniques. METHODOLOGY/PRINCIPAL FINDINGS Formation of strong complexes of BSA with both iminium and alkanolamine forms was revealed from fluorescence quenching of sanguinarine. Binding parameters calculated from Stern-Volmer quenchi...