It has been indicated that activation of peripheral imidazoline I2-receptor (I-2R) may reduce the blood pressure in spontaneously hypertensive rats (SHRs). Also, guanidinium derivatives show the ability to activate imidazoline receptors. Thus, it is of special interest to characterize the I-2R using guanidinium derivatives in blood vessels for development of antihypertensive agent(s). Six guani...

A new family of imidazoline-arylene macrocycles have been constructed through the simultaneous formation of four imidazoline rings in one step. These macrocycles can efficiently complex with fullerenes C60 and C70 through the formation of ground-state complexes.

Non-adrenergic ligands that bind to imidazoline receptors (I-R), a selective ligand that binds to alpha2-adrenoceptors (alpha2-AR) and mixed ligands that bind to both receptors were tested for their action on water intake behavior of 24-h water-deprived rats. All drugs were injected into the third cerebral ventricle. Except for agmatine (80 nmol), mixed ligands binding to I-R/alpha2-AR such as ...

Integrated experimental and computational studies reveal a new mechanism for Fe-catalyzed imidazoline synthesis through combined nitrene transfer acetonitrile attack of styrenyl radical intermediate.

Compounds with an imidazoline or guanidinium moiety elicit a variety of stimulatory and inhibitory cell responses in both central and peripheral tissues. Many of these effects are mediated by interaction with alpha-adrenergic receptors, but these molecules also selectively recognize other membrane-bound proteins with high affinity. We used a functionalized derivative of the imidazoline molecule...

The effects of newly synthesized 5-imidazoline derivatives on the dose-response relationship to norepinephrine were investigated in the normal and denervated vasa deferentia of the rat. Three derivatives (K-3827, K-4011 and K-4300) exerted alpha-antagonistic action, the potency of which was similar to that of tolazoline. The pA2 values of these derivatives and currently known alpha-antagonists ...

in this study using clonidine (a mixed ?2 /i1 receptors agonist), tizanidine (pure ?2-receptor agonist), rilmenidine (i1 receptor agonist) and yohimbine (?2-receptor antagonist), we tried to clarify the role of imidazoline and ?2-receptors in morphine withdrawal syndrome. morphine-dependence was induced by administration of increasing doses of morphine in mice. after the last administration of ...

Imidazoline receptors are divided into I(1) and I(2) subtypes. I(1)-imidazoline receptors are distributed in the heart and are upregulated during hypertension or heart failure. The aim of this study was to define the possible role of I(1)-imidazoline receptors in the regulation of atrial natriuretic peptide (ANP) release in hypertrophied atria. Experiments were performed on isolated, perfused, ...

Unexpected colloidal assemblies form in aqueous mixtures of sodium dodecylbenzenesulfonate (SDBS) with the following imidazoline compounds: 2,2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (V-44, which is a commonly used free-radical initiator), 2,2'-tetramethylenedi-2-imidazoline (TMI), and the main recombination product (RP) from the decomposition of V-44. All of these imidazoline co...