In view of potential biological activities of small molecule polyamides, we synthesized some novel N-(2-aminoethyl)-1-benzyl-2- (alkylthio)-1H-imidazole-5-carboxamide (7a,b), and N-(2-(1-benzyl-2-(alkylthio) -1H-imidazole- 5-carboxamido) ethyl)-1-benzyl-2- (alkylthio)-1H-imidazole-5-carboxamides (8a,b) as antitumor agents. The antitumor activity of compounds 7a,b and 8a,b was studied at c...

Although our recent studies revealed that under Ar microwave plasma conditions reactions of imidazole with poly(dimethylsiloxane) (PDMS) result in the formation of Si-CH2-imidazole species, the issue of the discharge gas effect on microwave plasma reactions remain unanswered. This study examines how these reactions in the presence of Ar, O2, and CO2 gases under microwave plasma conditions will ...

Imidazole, given intraperitoneally to rabbits, inhibited the prostaglandin E1-induced (PGE1) elevation of intraocular pressure. The maximum imidaz-le effect occurred at three to six hours after intraperitoneal infection. The prostaglandin E1-induced aqueous humor protein elevation was reduced markedly in the imidazole-pretreated rabbits. Intravenous administration of imidazole also was effectiv...

Abstract A straightforward ferrocyanide immobilization on the surface of graphene oxide (GO) was conducted for rapid and efficient adsorption capacity lanthanum praseodymium from an aqueous solution. The GO mixed with 1-methyl imidazole in presence epichlorohydrin to form GO-imidazole-Cl thereafter suspended a potassium solution fabricate GO-imidazole-FeCN. prepared materials were characterized...

The imidazole ring is part of the lateral chain of histidine. One of the main features of this amino acid is the ability to coordinate copper, especially Cu(2+), because of the intermediate base nature of its imidazole ring, which has a great biological relevance. Proteins such as cytochrome c oxidase, a crucial enzyme in the respiratory chain, and β-amyloid peptide, implicated in the pathology...

Imidazole, an organic alkaloid, is an important pharmacophore in drug discovery. Anti-neoplastic potential of imidazole derivatives has been documented in several studies; however, mechanisms by which tumor cells respond to these stimuli remain to be elucidated. Autophagy and apoptosis have key roles in tumorigenesis and tumor treatment. In this study, we systematically examined autophagic even...

Low-temperature studies of the simple variously substituted imidazole types 4-phenyl-1H-imidazole, C9H8N2, 1-benzyl-1Himidazole, C10H10N2, and 1-mesityl-1H-imidazole, C12H14N2, extend comparisons between parent imidazole species and their derivatives, the pronounced double-bond localization opposite the substituted N atom common to simple neutral species being redistributed aromatically on prot...

Since imidazole buffers have been used in platelet function tests and the compound has been reported to alter several biochemical activities of platelets, it seemed important to determine whether imidazole influenced platelet aggregation. ADP-induced, collagen-induced, and norepinephrine-induced platelet aggregations were tested in platelet-rich plasma by turbidimetric techniques. Glass beadind...

Silver complexes with 5-(4-(tert-butyl)-1H-imidazol-1-yl)-imidazo[1,5-a]pyridin-3-ylidene ligands were synthesized as metal-imidazole acid-base cooperative catalysts. Single crystal XRD analysis revealed that the silver atom was located in vicinity of imidazole ring and cationic formed dimers through coordination between metal pendant. These served catalysts for cyclization alkyne-tethered carb...