Introduction: Immune mediated hemolytic anemia (IMHA) is one of the most common immune mediated conditions in dogs treated in both the primary care and referral settings. Despite decades of knowledge and research on IMHA, it remains to be a frustrating and very deadly disease with reported mortality rates range from 22-70%. Although the highest mortality rates were seen in the earlier studies, ...

This paper proposes methods to improve Monte Carlo estimates when the Independent MetropolisHastings Algorithm (IMHA) is used. Our rst approach uses a control variate based on the sample generated by the proposal distribution. We derive the variance of our estimator for a xed sample size n and show that, as n tends to in nity, this variance is asymptotically smaller than the one obtained with t...

TARGET ANTIGENS IN CANINE IMMUNE-MEDIATED HEMOLYTIC ANEMIA Emmeline Ong Tan Advisor: University of Guelph, 2010 Dr. Darren Wood Primary immune-mediated hemolytic anemia (IMHA) is an important cause of serious morbidity and mortality in dogs. Despite numerous studies examining the demographics, treatment options, and prognostic indicators of disease, the mechanisms that underlie immune dysregula...

BACKGROUND Immune-mediated haemolytic anaemia (IMHA) is reported to be the most common autoimmune disease of dogs, resulting in significant morbidity and mortality in affected animals. Haemolysis is caused by the action of autoantibodies, but the immunological changes that result in their production have not been elucidated. AIMS To investigate the frequency of regulatory T cells (Tregs) and ...

BACKGROUND Difficulties with the direct antiglobulin test (DAT) and its apparent lack of sensitivity and specificity for immune-mediated hemolytic anemia (IMHA) in dogs have raised skepticism regarding its diagnostic value. OBJECTIVE To compare different DATs and other hematologic parameters in dogs. ANIMALS Anticoagulated blood samples from 59 nonanemic and 46 anemic dogs (± IMHA) from a r...

The mortality for dogs with severe immune-mediated hemolytic anemia (IMHA) is unacceptably high, and better immunosuppressive regimens are needed to increase survival. Understanding the basic immunology of the disease and the mechanisms of action of the available immunosuppressive therapies will help clinicians choose an appropriate immunosuppressive protocol. Prospective, randomized clinical s...

Immune mediated hemolytic anemia (IMHA) and immune mediated thrombocytopenia (IMTP) are common hematologic disorders in dogs resulting in red blood cell or platelet destruction which can lead to anemia or bleeding with corresponding clinical manifestations. Magnitude of clinical illness ranges from mild to severe; mortality rates as high as 80% and 50% have been reported in the veterinary liter...

Immune-mediated hemolytic anemia (IMHA) is a common cause of anemia in dogs and a primary idiopathic or autoimmune form of the disease is considered to be the most frequent form of IMHA in this species. Anemia may be severe and recurrent, with a mortality rate up to 70% according to certain publications. Diagnostic trail, appropriate treatment and potential prognosis depend on an understanding ...

■ Good quality IMHA services are easy to find and contact, and have the confidence and trust of the service user. They enable the person to express their views and be active participants in their care and treatment under the Mental Health Act. ■ IMHA services need to be commissioned in an informed way: investment needs to match local need and potential demand, and should be grounded in an under...

BACKGROUND Immune-mediated hemolytic anemia (IMHA) in dogs has a high risk of thrombosis and is associated with marked neutrophilia and necrosis. Cell death and release of neutrophil extracellular traps contribute to increased serum concentrations of cell-free DNA, and in human autoimmune disease reduced DNase activity further increases cell-free DNA. Free DNA in blood has prothrombotic propert...