نتایج جستجو برای: il2ra
تعداد نتایج: 257 فیلتر نتایج به سال:
OBJECTIVE IL2RA/CD25, the gene for interleukin-2 receptor alpha, is emerging as a general susceptibility gene for autoimmune diseases because of its role in the development and function of regulatory T cells and the association of single-nucleotide polymorphisms (SNPs) within this gene with type 1 diabetes mellitus (DM), Graves' disease, rheumatoid arthritis (RA), and multiple sclerosis (MS). T...
The mechanism for the association of type 1 diabetes (T1D) with IL2RA remains to be clarified. Neither of the two distinct, transmission-disequilibrium confirmed loci mapping to this gene can be explained by a coding variant. An effect on the levels of the soluble protein product sIL-2RA has been reported but its cause and relationship to disease risk is not clear. To look for an allelic effect...
Multiple sclerosis (MS) and type 1 diabetes (T1D) are organ-specific autoimmune disorders with significant heritability, part of which is conferred by shared alleles. For decades, the Human Leukocyte Antigen (HLA) complex was the only known susceptibility locus for both T1D and MS, but loci outside the HLA complex harboring risk alleles have been discovered and fully replicated. A genome-wide a...
INTRODUCTION Although rheumatoid arthritis (RA) is generally a chronic disease, a proportion of RA-patients achieve disease-modifying antirheumatic drug (DMARD)-free sustained remission, reflecting loss of disease-persistence. To explore mechanisms underlying RA-persistence, we performed a candidate gene study. We hypothesized that variants associating with lack of radiographic progression also...
به منظور بررسی تنوع ژنتیکی جمعیت بز سرخ جبالبارز با استفاده از 8 نشانگر ریزماهواره، شامل BM1312، MAF64، ILSTS034، ILSTS059، OraFCB20، IL2RA، LSCV24 و LSCV11 مطالعه شد. نمونه خون از 100 راس بز سرخ جبالبارز از ده گله به صورت تصادفی گرفته شد و تخلیص DNA با استفاده از کیت DIATOM DNA PREP انجام گرفت. واکنش زنجیره‌ای پلیمراز برای این جایگاه‌ها انجام گرفت و تمامی هشت جایگاه مورد مطالعه از چند شکلی منا...
Renal dysfunction post liver transplantation (LT) is common. We report our real-world experience of IL2Ra induction with immediate exposure to reduced dose tacrolimus used for patients chronic kidney disease (CKD) and evolving acute injury (AKI). A single-centre retrospective analysis elective adult LT from 1/1/17 31/12/17. The primary outcome measure was increase in CKD stage at month 6 post-L...
Cytokines critically control immune responses, but how regulatory programs are altered to allow T cells to differentially respond to distinct cytokine stimuli remains poorly understood. Here, we have globally analyzed enhancer elements bound by IL-2-activated STAT5 and IL-21-activated STAT3 in T cells and identified Il2ra as the top-ranked gene regulated by an IL-2-activated STAT5-bound superen...
Introduction: A variety of genetic predisposing factors and environmental factors are known to influence the pathogenesis of type-1 diabetes (T1D). This study intended to investigate the association of cytotoxic T-lymphocyte associated protein 4 (CTLA4) and interleukin 2 receptor subunit alpha (IL2RA) gene polymorphisms with type 1 diabetes in children of northwest of Iran. Methods: Genomic DNA...
به منظور بررسی تنوع ژنتیکی جمعیت بز سرخ جبالبارز با استفاده از 8 نشانگر ریزماهواره، شامل bm1312، maf64، ilsts034، ilsts059، orafcb20، il2ra، lscv24 و lscv11 مطالعه شد. نمونه خون از 100 راس بز سرخ جبالبارز از ده گله به صورت تصادفی گرفته شد و تخلیص dna با استفاده از کیت diatom dna prep انجام گرفت. واکنش زنجیره ای پلیمراز برای این جایگاه ها انجام گرفت و تمامی هشت جایگاه مورد مطالعه از چند شکلی منا...
BACKGROUND IL-2 receptor (IL2R) alpha is the specific component of the high affinity IL2R system involved in the immune response and in the control of autoimmunity. METHODS AND RESULTS Here we perform a replication and fine mapping of the IL2RA gene region analyzing 3 SNPs previously associated with multiple sclerosis (MS) and 5 SNPs associated with type 1 diabetes (T1D) in a collection of 79...
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