نتایج جستجو برای: igf2

تعداد نتایج: 1482  

2018
Quanwei Zhang Qi Wang Jishang Gong Jiaxing Du Yong Zhang Xingxu Zhao

Insulin-like growth factor 2 (IGF2) recapitulates many of the activities of insulin and promotes differentiation of myoblasts and osteoblasts, which likely contribute to genetic variations of growth potential. However, little is known about the functions and signaling properties of IGF2 variants in yaks. The over-expression vector and knockdown sequence of yak IGF2 were transfected into yak fib...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1995
T Taniguchi M J Sullivan O Ogawa A E Reeve

In most tissues IGF2 is expressed from the paternal allele while H19 is expressed from the maternal allele. We have previously shown that in some Wilms tumors the maternal IGF2 imprint is relaxed such that the gene is expressed biallelically. We have now investigated this subset of tumors further and found that biallelic expression of IGF2 was associated with undetectable or very low levels of ...

Journal: :Cancer research 1997
N Nonomura K Nishimura T Miki N Kanno Y Kojima M Yokoyama A Okuyama

Loss of imprinting (LOI) has been implicated in the pathogenesis of embryonal malignancies as well as adult cancers. Insulin-like growth factor II (IGF2) gene is an imprinted gene, normally transcribed only from the paternal allele. We investigated allele-specific expression of the IGF2 gene in 22 cases of renal cell carcinoma (RCC), a common adult-onset renal tumor. Sixteen cases (72%) were in...

Journal: :The Journal of biological chemistry 2014
Honey Modi Marion Cornu Bernard Thorens

IGF2 is an autocrine ligand for the beta cell IGF1R receptor and GLP-1 increases the activity of this autocrine loop by enhancing IGF1R expression, a mechanism that mediates the trophic effects of GLP-1 on beta cell mass and function. Here, we investigated the regulation of IGF2 biosynthesis and secretion. We showed that glutamine rapidly and strongly induced IGF2 mRNA translation using reporte...

Journal: :Gerontology 2013
Daniel Bergman Matilda Halje Matilda Nordin Wilhelm Engström

BACKGROUND Insulin-like growth factor 2 (IGF2) is a protein hormone known to regulate cell proliferation, growth, migration, differentiation and survival. The gene is parentally imprinted in the sense that transcripts are almost exclusively derived from the paternal allele. Loss of imprinting of the IGF2 gene is a recurrent observation in growth disorders that combine overgrowth with a variety ...

2016
Xin Zhao Xiaoliang Liu Guanjun Wang Xue Wen Xiaoying Zhang Andrew R. Hoffman Wei Li Ji-Fan Hu Jiuwei Cui

Insulin-like growth factor II (IGF2) is maternally imprinted in most tissues, but the epigenetic regulation of the gene in cancer stem cells (CSCs) has not been defined. To study the epigenetic mechanisms underlying self-renewal, we isolated CSCs and non-CSCs from colon cancer (HT29, HRT18, HCT116), hepatoma (Hep3B), breast cancer (MCF7) and prostate cancer (ASPC) cell lines. In HT29 and HRT18 ...

Journal: :Human molecular genetics 2004
Maria Vernucci Flavia Cerrato Paolo V Pedone Luisa Dandolo Carmelo B Bruni Andrea Riccio

Igf2 and H19 are physically linked imprinted genes. In embryonic liver, their reciprocal expression (paternal for Igf2 and maternal for H19) is controlled by a paternally methylated region (H19 DMD) located 5' of H19. This region contains a methylation-sensitive insulator that prevents the Igf2 promoters being activated by downstream enhancers on the maternal chromosome. In adult liver, Igf2 is...

Journal: :The Journal of biological chemistry 2004
Vivian X Fu Steven R Schwarze Michelle L Kenowski Scott Leblanc John Svaren David F Jarrard

The imprinted insulin-like growth factor-2 (IGF2) gene is an auto/paracrine growth factor expressed only from the paternal allele in adult tissues. In tissues susceptible to aging-related cancers, including the prostate, a relaxation of IGF2 imprinting is found, suggesting a permissive role for epigenetic alterations in cancer development. To determine whether IGF2 imprinting is altered in cell...

Journal: :Neuro-oncology 2022

Abstract While loss of RB function is the most common genetic alteration in pediatric embryonal eye tumor retinoblastoma, mutations leading to BCL-6 corepressor (BCOR) are second alteration. BCOR found more aggressive tumors, and associated with metastasis poor prognosis. We investigated effects or overexpression retinoblastoma cells order better understand its functional role, determine if it ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
T Forné J Oswald W Dean J R Saam B Bailleul L Dandolo S M Tilghman J Walter W Reik

Recent investigations have shown that the maintenance of genomic imprinting of the murine insulin-like growth factor 2 (Igf2) gene involves at least two factors: the DNA (cytosine-5-)-methyltransferase activity, which is required to preserve the paternal specific expression of Igf2, and the H19 gene (lying 90 kb downstream of Igf2 gene), which upon inactivation leads to relaxation of the Igf2 i...

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