Background IgA Deficiency (IgAD) is the most common immunoglobulin deficiency, with approximate incidence of 1 in 400 to 3000 individuals in general population. Selective IgA deficiency is defined as serum IgA levels less than 7 mg/dL with normal serum IgM and IgG levels. A subgroup of individuals, with more than 7 mg/dL but less than 30 mg/dL of serum IgA, are defined as partial IgA deficient ...

Patients with selective immunoglobulin (Ig) A deficiency have a 10- to 20-fold increased risk of celiac disease. In these patients, serological diagnosis of celiac disease can be difficult, since specific IgA-based assays are usually negative and IgG-specific antibody tests are insufficiently reliable. We describe a girl with selective IgA deficiency who had a troublesome diagnosis of celiac di...

Dietary methionine (met) is reported to enhance antibody production and boost cell-mediated immunity in chickens. Methionine deficiency has been shown to affect the development of the lymphoid organs and the generation of antibodies in chickens. This study is designed to investigate the effects of met deficiency on IgA+ B cells and immunoglobulins (sIgA, IgA, IgG and IgM) for a 6 wee...

BACKGROUND Selective immunoglobulin A (IgA) deficiency is the most common inherited immunodeficiency disorder worldwide. An early diagnosis is advocated because of the increased risk of infections, autoimmune diseases, and allergic reactions. We investigated the usefulness of a rapid point-of-care test in detecting for IgA deficiency in a population with a previously unknown prevalence. MATERIA...

Immunoglobulin A (IgA) deficiency occurs more frequently in patients with celiac disease (CD) than in the general population and can lead to false-negative results in the best serologic test for CD, endomysial IgA (EMA). To evaluate the impact of IgA deficiency on serologic detection of CD in a reference laboratory setting, IgA levels were measured in 510 consecutive serum specimens submitted f...

IgA is one of the five classes of immunoglobulin found in biological fluids. It is the major secretory immunoglobulin and is widely distributed in all mucosal secretions as a dimeric molecule linked by a joining chain and a third molecule, the secretory piece. The dimeric form is resistant to proteolytic digestion and IgA antibodies are important in the protection of mucous membranes against in...

IgA is one of the five classes of immunoglobulin found in biological fluids. It is the major secretory immunoglobulin and is widely distributed in all mucosal secretions as a dimeric molecule linked by a joining chain and a third molecule, the secretory piece. The dimeric form is resistant to proteolytic digestion and IgA antibodies are important in the protection of mucous membranes against in...