Interferon (IFN)-based therapy, the cornerstone for treatment of hepatitis C virus (HCV) infection, is generally considered to be the single most effective treatment strategy for this infection. Although most adverse effects of IFN therapy respond very well to the cessation of this drug, there are reports of serious irreversible adverse effects. This review article evaluates the adverse effects...

background chronic hepatitis b is one of the most common causes of cirrhosis and hepatocellular toxicity in many countries, including iran. cytotoxic t lymphocyte (ctl) and natural killer (nk) cells are the two of main cell populations considered as cytotoxic cells. one of the distinct pathways ctl and nk cells exert cytotoxicity is perforin/granzyme. after the cytotoxic cell/target cell juncti...

background: tuberculosis (tb) remains an important health problem throughout the world. despite its significance in public health, mechanisms of protective immunity against mycobacyerium tuberculosis in humans have not yet been understood. objective: to evaluate cell mediated immune response against purified ag 85, ppd and phytohemagglutinin (pha) in patients with tuberculosis and healthy tuber...

Inborn errors of TLR3-dependent IFN-α/β– and IFN-λ–mediated immunity in the CNS can underlie herpes simplex virus 1 (HSV-1) encephalitis (HSE). The respective contributions IFN-α/β IFN-λ are unknown. We report a child homozygous for genomic deletion entire coding sequence part 3′-UTR last exon IFNAR1, who died HSE at age 2 years. An older cousin following vaccination against measles, mumps, rub...

Rodent-borne orthohantaviruses are asymptomatic in their natural reservoir, but they can cause severe diseases humans. Although an exacerbated immune response relates to hantaviral pathologies, have antagonize the antiviral interferon (IFN) successfully propagate infected cells. We studied interactions of structural and nonstructural (NSs) proteins pathogenic Puumala (PUUV), low-pathogenic Tula...

Background: As a T helper type 1 (Th1) derived cytokine, Interferon gamma (IFN-γ) is an important regulator of inflammatory immune responses. Furthermore, IFN-γ plays an essential role in defense against tumors and intracellular pathogens. This study was designed to assess the pattern of IFN-γ production in human leukemic (Jurkat and Molt-4) T cell lines in vitro. Methods: Ju...

It is now well documented that interferon gamma (IFN-γ) is the indispensable cytokine for inducing protective immunity against experimental and human cutaneous leishmaniaisis. The importance of IFN-γ receptor (IFN-γR) has also been studied. In the present study, we made attempts to find out whether L. major infection is able to alter the expression of IFN-γR in vivo. In addition, we studied the...