Acyl glucuronides (AGs) formed from carboxylic acid-containing drugs have been considered to be a cause of idiosyncratic drug toxicity (IDT). Chemical stability of AGs is supposed to relate to their reactivity. In this study, the half-lives of 21 AGs of carboxylic drugs in potassium phosphate buffer (KPB), human serum albumin (HSA) solution, and human fresh plasma were analyzed in relation to t...

BACKGROUND Implementing the treatment arm of a clinical trial often requires changes to healthcare practices. Barriers to such changes may undermine the delivery of the treatment making it more likely that the trial will demonstrate no treatment effect. The 'Major outcomes with personalized dialysate temperature' (MyTEMP) is a cluster-randomised trial to be conducted in 84 haemodialysis centres...

Accurate registration is crucial for medical image analysis. In this letter, we proposed an improved Demons technique (IDT) for medical image registration. The IDT improves registration quality using orthogonal gradient information. The advantage of the proposed IDT is assessed using 14 medical image pairs. Experimental results show that the proposed technique provides about 8% improvement over...

The telling of atrocity stories offers therapeutic benefits to healthcare providers. Transcripts of hospice interdisciplinary team (IDT) meetings were used to analyze strategies for telling atrocity stories in the performance of symbiotic niceness through criticism. Symbiotic niceness draws upon niceness messages to establish reciprocal niceness by others in order to facilitate emotional labor....

The residual activity of Lactobacillus delbrueckii ssp. bulgaricus cultures was analysed using pH and various impedimetric methods (impedance detection time (IDT), conductance and capacitance) to quantify the loss in activity following freeze-drying. The large variation recorded in IDT values for similar levels of activity suggests that IDT is not an adequate parameter for estimating the cultur...

This paper argues that an emphasis on training-for-the-job approaches has distracted designers from thinking about the meaning of their profession and the grand purpose of practising instructional design. Drawing from literature in the fields of sociology and educational technology, this paper synthesises discourses on civic professionalism in instructional design and technology, and proposes a...

A screening test for the diagnosis of tuberculosis by immunodot (IDt) is described, using an antigen of Mycobacterium tuberculosis, namely, a 38-kDa glycoprotein which has shown great specificity in previous serologic analyses. The test was used to examine 28 sera from patients with lung tuberculosis. Of these, 85% were positive by micro-ELISA and by the IDt test herein described. Control sera ...

Registration techniques have many applications such as 3D scans alignment, panoramic image mosaic creation or shape matching. This paper focuses on (2D) point cloud registration using novel iterative algorithms that are inspired by the Iterative Distribution Transfer (IDT) algorithm originally proposed to solve colour transfer [Pitié et al., 2005, Pitié et al., 2007]. We propose three variants ...

An interrupt descriptor table (IDT) is used by the processor to transfer the execution of a program to special software routines that handle interrupts, which might be raised during the normal course of operation by hardware or to signal exceptional conditions, such as a hardware failure. Attackers frequently modify the pointers in the IDT in order to execute malicious code. In this paper we pr...

Workflow model performance analysis plays an important role in the research of workflow techniques and efficient implementation of workflow management. Instances dwelling times (IDT) which consist of waiting times and handle times in a workflow model is a key performance analysis goal. In a workflow model the instances which act as customers and the resources which act as servers form a queuing...