Hyperlipidemia of nephrotic origin could potentially cause glomerular injury as well as increase the risk of atherosclerosis. The precise interaction of human lipoproteins abnormal in lipid and protein composition, with lipoprotein receptors has not been clearly defined. This study examines receptor-mediated uptake and intracellular cholesterol metabolism of apolipoprotein (apo)B,E containing i...

Peptides derived from the C-terminal heptad repeat (CHR) of HIV gp41 have been developed as effective fusion inhibitors against HIV-1, but facing the challenges of enhancing potency and stability. Here, we report a rationally designed novel HIV-1 fusion inhibitor derived from CHR-derived peptide (Trp628~Gln653, named CP), but with an innovative Ile-Asp-Leu tail (IDL) that dramatically increased...

IDL (Intelligent Digital Library) is a prototypical intelligent digital library service that is currently being developed at the University of Bari. Among the characterizing features of IDL there are a retrieval engine and several facilities available for the library users. In this paper, we present the web-based visual environment we have developed with the aim of improving the user-library in...

The conversion of very low density (VLDL) to low density lipoproteins (LDL) is a two-step process. The first step is mediated by lipoprotein lipase, but the mechanism responsible for the second is obscure. In this study we examined the possible involvement of receptors at this stage. Apolipoprotein B (apoB)-containing lipoproteins were separated into three fractions, VLDL (Sf 100-400), an inter...

We studied the metabolism of very low density lipoprotein (VLDL) and intermediate density lipoprotein (IDL) particles that did or did not have apolipoprotein E (apoE) in 12 normolipidemic women by endogenously labeling plasma apolipoprotein B. The plasma was separated into bound (E+) and unbound (E-) fractions by use of a monoclonal antibody (1D7), and the fractions were ultracentrifuged to yie...

Communication in microkernel-based systems is much more frequent than system calls known from monolithic kernels. This can be attributed to the placement of system services into their own protection domains. Communication has to be fast to avoid unnecessary overhead. Also, communication channels in microkernel-based systems are used for more than just remote procedure calls. In distributed syst...

Low density lipoprotein (LDL) and intermediate density lipoprotein (IDL) classes have been shown to be composed of discrete metabolic entities or subclasses. Present ultracentrifugal methods are unable to precisely determine these subclasses. A new analytical micro-ultracentrifugal method was developed that facilitates the determination of IDL and LDL subclasses and their F1.21 flotation coeffi...

Studies were undertaken to determine whether there is an association between elevated levels of intermediate-density lipoproteins (IDL) (Sf 12-60 lipoproteins) and coronary artery disease. Forty-five to sixty-five-year-old men with objectively documented coronary artery disease (n = 58) who were free of known risk factors (diabetes, hypertension, obesity, hyperuricemia, and hypercholesterolemia...

This paper presents our experiments in providing mechanisms for parametric polymorphism for computer algebra software components. Specific interfaces between Aldor and C++ and between Aldor and Maple are described. We then present a general solution, Generic IDL (GIDL), an extension to CORBA IDL supporting generic types. We describe our language bindings for C++, Java 1.5 and Aldor as well as a...