Background. The natural history of idiopathic membranous nephropathy and recurrent disease in transplants is variable. We performed a retrospective cohort study of renal transplant recipients with a primary diagnosis of idiopathic membranous nephropathy. We aimed to establish patterns of disease recurrence and to identify factors associated with disease recurrence. Methods. We accessed the Iris...

risks of death, cardiovascular events, and hospitalization. N Engl J Med 2004; 351: 1296–1305 32. Fort J. Chronic renal failure: a cardiovascular risk factor. Kidney Int Suppl 2005; S25–S29 33. Collins AJ, Foley RN, Herzog C et al. United States Renal Data System 2008 Annual Data Report Abstract. Am J Kidney Dis 2009; 53: S8–S374 34. Kasiske BL, Snyder JJ, Gilbertson DT et al. Cancer after kidn...

Exciting progress recently has been made in our understanding of idiopathic membranous nephropathy, as well as treatment of this disease. Here, we review important advances regarding the pathogenesis of membranous nephropathy. We will also review the current approach to treatment and its limitations and will highlight new therapies that are currently being explored for this disease including Ri...

INTRODUCTION Idiopathic Membranous Nephropathy (MN) is a common cause of adult nephrotic syndrome. Recently, M-type phospholipase A2 receptor (PLA2-R) has been discovered as the main podocyte antigen in the pathogenesis of idiopathic MN. MATERIALS AND METHODS In this mini review, the author searched English-language MEDLINE for the terms "membranous nephropathy", "rituximab", and "phospholipa...

BACKGROUND The diagnosis of MN is made on kidney biopsy. Diagnostic features include capillary wall thickening, normal cellularity, IgG and C3 along capillary walls on immunofluorescence, and subepithelial deposits on electron microscopy. MN is often seen in association with an underlying disorder (secondary MN). Secondary MN is more common in children (75%) than adults (25%) (Table 12). The di...