نتایج جستجو برای: id50

تعداد نتایج: 265  

Journal: :Journal of applied physiology 1999
C Campo J F Molinari J Ungo T Ahmed

We have hypothesized that antiallergic activity of inhaled heparin is molecular weight dependent and mediated by "nonanticoagulant fractions" (NAF-heparin). Therefore, we studied comparative effects of high-, medium-, and ultralow-molecular-weight (HMW, MMW, and ULMW, respectively) NAF-heparins on acute bronchoconstrictor response (ABR) and airway hyperresponsiveness (AHR) in allergic sheep. Sp...

Journal: :Viruses 2023

The SARS-CoV-2 pandemic demonstrated the need for potent and broad-spectrum vaccines. This study reports development testing of a lumpy skin disease virus (LSDV)-vectored vaccine against SARS-CoV-2, utilizing stabilized spike conserved nucleocapsid proteins as antigens to develop robust immunogenicity. Construction (LSDV-SARS2-S,N) was confirmed by polymerase chain reaction (PCR) amplification ...

Journal: :Archivum immunologiae et therapiae experimentalis 2000
M Z Wiśniewski J Wietrzyk A Opolski

A number of co-ordination compounds of Ru(III), Rh(III), Pd(II) and Pt(II) with ligands incorporating azole and pyrimidine rings has been synthesized. The in vitro cell proliferation-inhibitory activity of these compounds was examined against human cancer cell lines: A 549 (lung carcinoma), LS-180 (colon cancer) and MCF-7 (breast cancer), using SRB technique. Six out of 13 compounds studied rev...

2013
Christopher Steven Eickhoff Brian Anthony Dunn Nicole Lea Sullivan Daniel Fredric Hoft

Trypanosoma cruzi infects humans when infected triatomine vector excreta contaminate breaks in skin or mucosal surfaces. T. cruzi insect-derived metacyclic trypomastigotes (IMT) invade through gastric mucosa after oral challenges without any visible inflammatory changes, while cutaneous and conjunctival infections result in obvious local physical signs. In this study we compared the infectivity...

Journal: :Occupational and environmental medicine 1994
M Iwata Y Nishihara Y Watanabe M Miyahara K Saeki

The effects of hexachlorobiphenyls (HCBs) on superoxide (O2-) generation by guinea pig polymorphonuclear leucocytes were examined. 2,3,6,2',3',6'-HCB by itself had only a weak inductive effect on O2- generation. This compound, however, enhanced O2- generation stimulated by N-formyl-methionyl-leucyl-phenylalanine (FMLP) about twofold, but not the generation induced by phorbol myristate acetate (...

ژورنال: :دامپزشکی ایران 0

اطلاع از دوز عفونی کننده عوامل عفونی لازمه ارزیابی های تجربی واکسن های تولید شده بر ضد آن عامل می باشد.  با وجود این که باکتری تروپرلا پیوژنز باعث بیماری های مختلفی در دام ها می شود‏‏، اطلاع کمی در مورد دوز عفونی کننده آن در دام های اهلی موجود است.  این مطالعه به منظور تعیین دوز عفونی زای پنجاه درصد (id50) تروپرلا پیوژنز در گوسفند انجام شد.  برای این منظور چهار گروه سه راسی (a تا d)، از بره های...

Journal: :Circulation research 1981
R Towart

I studied the role of calcium in the activation of isolated rings of saphenous and basilar arteries of the rabbit by comparing the effect of calcium withdrawal with the effect of the calcium antagonist nimodipine [isopropyl(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate]. Serotonin-induced contractions of both vessels were inhibited quickly by incubation in...

2011
Luiz F. M. Izidoro Lívia M. Alves Veridiana M. Rodrigues Deise A. O. Silva José R. Mineo

The effect of an L-amino acid oxidase isolated from Bothrops pirajai snake venom (BpirLAAO-I) was investigated on infection of Toxoplasma gondii in human foreskin fibroblasts (HFF). The cytotoxic activity of BpirLAAO-I on HFF cells showed a dose-dependent toxicity with median cytotoxic dose (TD50) of 11.8 μg/mL. BpirLAAO-I induced considerable dose-dependent decrease in the T. gondii infection ...

Journal: :Journal of applied physiology 1998
J Martinez-Salas R Mendelssohn W M Abraham B Hsiao T Ahmed

Inhaled heparin prevents antigen-induced bronchoconstriction and inhibits anti-immunoglobulin E-mediated mast cell degranulation. We hypothesized that the antiallergic action of heparin may be molecular weight dependent. Therefore, we studied the effects of three different low-molecular-weight fractions of heparin [medium-, low-, and ultralow-molecular-weight heparin (MMWH, LMWH, ULMWH, respect...

Journal: :Blood 1985
S Siena H Castro-Malaspina S C Gulati L Lu M O Colvin B D Clarkson R J O'Reilly M A Moore

UNLABELLED We describe the effects of 4-hydroperoxycyclophosphamide (4-HC) on the hematopoietic and stromal elements of human bone marrow. Marrow cells were exposed to 4-HC and then assayed for mixed (CFU-Mix), erythroid (BFU-E), granulomonocytic (CFU-GM), and marrow fibroblast (CFU-F) colony-forming cells and studied in the long-term marrow culture (LTMC) system. The inhibition of colony forma...

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