نتایج جستجو برای: ich
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INTRODUCTION Spontaneous intracerebral hemorrhage (ICH) is one of leading causes of mortality and morbidity worldwide. Several predictive models have been developed for ICH; however, none of them have been consistently used in routine clinical practice or clinical research. In the study, we aimed to develop and validate a risk score for predicting 1-year functional outcome after ICH (ICH Functi...
OBJECTIVE In the so-called primary intracerebral hemorrhage (ICH), lobar and deep ICH were mainly due to cerebral amyloid angiopathy and deep perforating arterial disease. Our aim was to identify specifics of warfarin associated ICH (WAICH) and to focus on differences in susceptibility to warfarin according to the underlying vasculopathies, expressed by ICH location. MATERIALS AND METHODS We ...
OBJECTIVE Genetic variants ε2/ε4 within the APOE gene are established risk factors for lobar intracerebral hemorrhage (ICH). Published preliminary data suggest a potential role for APOE ε4 in risk of nonlobar ICH. We therefore investigated the role of APOE in recurrent nonlobar ICH, and sought to clarify whether effects of APOE on circulating lipids mediate this association. METHODS Three hun...
BACKGROUND AND PURPOSE Accurate estimates for risk and rates of intracranial hemorrhage (ICH) in the natural course of patients harboring brain arteriovenous malformation (BAVM) are needed to provide a quantitative basis for planning clinical trials to evaluate interventional strategies and to help guide practice management. METHODS We identified patients with BAVM at the Kaiser Permanente No...
BACKGROUND AND PURPOSE The characteristics of intracerebral hemorrhage (ICH) may vary by ICH location because of differences in the distribution of underlying cerebral small vessel diseases. Therefore, we investigated the incidence, characteristics, and outcome of lobar and nonlobar ICH. METHODS In a population-based, prospective inception cohort study of ICH, we used multiple overlapping sou...
OBJECTIVE We evaluated recurrent intracerebral hemorrhage (ICH) risk in ICH survivors, stratified by the presence, distribution, and number of cerebral microbleeds (CMBs) on MRI (i.e., the presumed causal underlying small vessel disease and its severity). METHODS This was a meta-analysis of prospective cohorts following ICH, with blood-sensitive brain MRI soon after ICH. We estimated annualiz...
Intracerebral hemorrhage (ICH) is a devastating condition. Existing preclinical ICH models focus largely on striatum but neglect other brain areas such as ventricle, cortex, and hippocampus. Clinically, however, hemorrhagic strokes do occur in these other brain regions. In this study, we established mouse hemorrhagic models that utilize stereotactic injections of autologous whole blood or colla...
background: intracerebral hemorrhage (ich) is a stroke type which resulted in disability. memantine have been supposed to have the effect on the functional status in patients with ich. objectives: comparing the effect of memantine with placebo on the clinical outcome of ich. materials and methods: this double-blind clinical trial was conducted in an academic hospital in northern iran on patien...
Intracerebral hemorrhage (ICH) accounts for 10 to 20% of all strokes. It is the leading cause of all strokes, second only to cerebral infarction [1]. Hypertension is the single most important risk factor for ICH, often leading to solitary ICH [2,3]. Though hypertension can lead to recurrent ICH, the occurrence of multiple simultaneous ICH is rare [4]. The occurrence of multiple simultaneous ICH...
BACKGROUND AND PURPOSE Intracerebral hemorrhage (ICH), the acute manifestation of a common progressive cerebrovascular disease of the elderly, is the most fatal and least treatable form of stroke. There is a desperate need for ICH-specific therapeutics and effective primary prevention strategies, a need that is certain to grow with the aging of the population. Data point to a sizable genetic co...
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