In an endeavor to further characterize human intercellular adhesion molecule-2 (ICAM-2), two murine monoclonal antibodies (mAb) were generated to ICAM-2 transfected COS cells, and designated CBR-IC2/1 and CBR-IC2/2. Immunoprecipitated, reduced ICAM-2 migrated as a broad band of Mr 60,000 in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Treatment with N-glycanase revealed a peptide ...

We have characterized the immunobiology of the interaction of intercellular adhesion molecule 3 (ICAM-3; CD50) with its counter-receptor, leukocyte function-associated antigen 1 (LFA-1; CD11a/CD18). Purified ICAM-3 supported LFA-1-dependent adhesion in a temperature- and cation-dependent manner. Activation of cells bearing LFA-1 increased adhesiveness for ICAM-3 in parallel to adhesiveness for ...

Intercellular adhesion molecule-1 (ICAM-1) is a target for drug delivery to endothelial cells (ECs), which internalize multivalent anti-ICAM nanocarriers (anti-ICAM/NCs) within 15 to 30 minutes. The concomitant ICAM-1 disappearance from the EC surface transiently inhibited subsequent binding and uptake of anti-ICAM/NCs. Within 1 hour, internalized ICAM-1 diverged from anti-ICAM/NCs into prelyso...

BACKGROUND During transendothelial migration, leukocytes use adhesion molecules, such as ICAM-1, to adhere to the endothelium. ICAM-1 is a dynamic molecule that is localized in the apical membrane of the endothelium and clusters upon binding to leukocytes. However, not much is known about the regulation of ICAM-1 clustering and whether membrane dynamics are linked to the ability of ICAM-1 to cl...

the purpose of this study was to examine the effect of aerobic training on levels of vascular and intracellular adhesion molecules in overweight middle-aged women. 20 sedentary obese women (mean+age: 46.1+6.88 years, bf%: 36.7+ 6.18, weight: 73.56+10 kg and bmi: 59.5+4.15 kg.m2) were selected and randomly divided into two groups. training program consisted of 50-60 min. running with an intensit...

introduction there is an agreement that eating disorder is related to psychological characteristics and on the other hand, level of ghrelin hormone, intercellular adhesion molecule-1 (icam-1) and e-selection also change during eating disorders. we aimed to study the relationship between eating disorders and rest levels, icam-1, e-selection, and ghrelin hormone in obese people. materials and met...