BACKGROUND The high iatrogenic multiple pregnancy rate associated with intrauterine insemination (IUI) in hyperstimulated cycles is becoming less acceptable. Therefore we investigated data from an earlier prospective trial with regard to the specific question of whether the application of mild hyperstimulation in IUI cycles could be an alternative strategy for obtaining acceptable pregnancy rat...

In the last 20 to 30 years, early diagnosis of pregnancy has markedly decreased ectopic pregnancy-related maternal mortality, and the necessity for surgical treatment. With modern approaches in the treatment of ectopic pregnancy, surgical therapy has been replaced by medical therapy and medical treatment by spontaneous follow-up in appropriate cases. However, this current trend has led to some ...

OBJECTIVES To describe the characteristics, management and outcomes of women giving birth at advanced maternal age (≥48 years). DESIGN Population-based cohort study using the UK Obstetric Surveillance System (UKOSS). SETTING All UK hospitals with obstetrician-led maternity units. POPULATION Women delivering at advanced maternal age (≥48 years) in the UK between July 2013 and June 2014 (n ...

To the Editor: It is common knowledge that the biomechanical stability of connective tissue changes during pregnancy, leading to reduced stiffness and increased extensibility. These changes are most probably hormone-induced and, therefore, corneal biomechanics also may change during pregnancy. Five patients who underwent LASIK experienced vision deterioration during pregnancy, which we attribut...

The epidemiology of iatrogenic disease in the elderly has not been extensively reported. Risk factors of iatrogenic disease in the elderly are drug-induced iatrogenic disease, multiple chronic diseases, multiple physicians, hospitalization, and medical or surgical procedures. Iatrogenic disease can have a great psychomotor impact and important social consequences. To identify patients at high r...

OBJECTIVE To examine the association between chronic hypertension (CH) and a wide range of adverse pregnancy outcomes after adjustment for confounding factors in obstetric history and maternal characteristics. METHODS This was a prospective screening study for adverse pregnancy outcomes in women with singleton pregnancy attending their first routine hospital visit at 11 + 0 to 13 + 6 weeks' g...

multiple sclerosis (ms) is the most common chronic autoimmune demyelinating disorder of the central nervous system (cns) which preferentially involves young women in early child bearing age. opposite to traditional view emphasized on discouraging female patients from enduring pregnancy, recent investigations showed that pregnancy-related physiological alterations, especially during the third tr...

BACKGROUND The present study used vital-statistics data to estimate the effect of maternal age and fertility treatment on the number and rate of multiple live births in Japan from 1974 through 2009. METHODS Japanese vital statistics published by the Ministry of Health, Labour and Welfare from 1974 to 2009 were gathered and reanalyzed with regard to maternal age class and plurality of live bir...

Multiple pregnancies associated with infertility treatment are recognized as an adverse outcome and are responsible for morbidity and mortality related to prematurity and very low birthweight population. Due to the epidemic of iatrogenic multiple births, the incidence of maternal, perinatal and childhood morbidity and mortality has increased. This results in a hidden healthcare cost of infertil...