Treatment of CuI with the flexible PhS(CH(2))(4)SPh dithioether ligand in MeCN solution affords the strongly luminescent metal-organic 2D coordination polymer [Cu(4)I(4){mu-PhS(CH(2))(4)SPh}(2)](n) (). The interpenetrated 2D network of is built upon by Cu(4)(mu(3)-I)(4) cubane-like clusters as secondary building units (SBUs), which are interconnected via bridging 1,4-bis(phenylthio)butane ligan...

Many vertebrate small nuclear RNA gene promoters contain an SPH motif in their distal control regions that can confer transcriptional stimulation by RNA polymerase II or RNA polymerase III. Using the human U6 gene SPH motif as a probe, we isolated a cDNA encoding human SPH-binding factor (hSBF) from a HeLa cell expression library. The coding region of hSBF is almost identical to ZNF143, a 626 a...

Independent of their etiology, all chronic liver diseases ultimately lead to liver cirrhosis, which is a major health problem worldwide. The underlying molecular mechanisms are still poorly understood and no efficient treatment strategies are available. This paper introduces the sinusoidal pressure hypothesis (SPH), which identifies an elevated sinusoidal pressure (SP) as cause of fibrosis. SPH...

a r t i c l e i n f o a b s t r a c t We present a methodology to concurrently couple particle-based methods via a domain decomposition (DD) technique for simulating viscous flows. In particular, we select two resolutions of the smoothed particle hydrodynamics (SPH) method as demonstration. Within the DD framework, a simulation domain is decomposed into two (or more) overlapping sub-domains, ea...

A simple short proof of the Johnson-Lindenstrauss lemma (concerning nearly isometric embeddings of finite point sets in lower-dimensional spaces) is given. This result is applied to show that if G is a graph on n vertices and with smallest eigenvalue i then its sphericity sph(G) is less than cA2 log n. It is also proved that if G or its complement is a forest then sph(G) < c log n holds. Q 19%8...

Because sphingosine (Sph) is actively incorporated into platelets and rapidly converted to sphingosine 1-phosphate (Sph-1-P), which is then released extracellularly, it is important to study the effects of Sph and Sph-1-P on endothelial cells from the viewpoint of platelet-endothelial cell interaction. In this study, we found that Sph, as well as ceramide, induces apoptosis in human umbilical v...

Event isotropy $\mathcal{I}^\text{sph}$, an event shape observable that measures the distance of a final state from spherically symmetric state, is designed for new physics signals are far QCD-like. Using technique producing wide variety can range near-spherical to jetty, we compare other observables. We show thrust $T$ and $C$ parameter (and $\lambda_\text{max}$, largest eigenvalue sphericity ...

Sphingosine 1-phosphate (Sph-1-P) has been implicated as an intracellular second messenger in many studies. We investigated the metabolism of Sph-1-P and the mechanism by which Sph-1-P induces activation in enucleated and highly differentiated platelets. Platelets lack Sph-1-P lyase activity, possess persistently active sphingosine (Sph) kinase, and abundantly store Sph-1-P. Although exogenous ...

Spectrin is the backbone of the erythroid cytoskeleton; sph/sph mice have severe hereditary spherocytosis (HS) because of a mutation in the murine erythroid alpha-spectrin gene. sph/sph mice have a high incidence of thrombosis and infarction in multiple tissues, suggesting significant vascular dysfunction. In the current study, we provide evidence for both pulmonary and systemic vascular dysfun...