Purpose. Physical activity is an integral part of the treatment of diabetes. The aim of the study was to assess aerobic capacity and cardiovascular-respiratory reactions to a single physical exercise with gradually increasing intensity in normobaric hypoxia in patients with Type 1 diabetes. Methods. The study was conducted on a sample of adults with Type 1 diabetes (GT1D, n = 13) and a randomly...

The most common pediatric mitochondrial disease is Leigh syndrome, an episodic, subacute neurodegeneration that can lead to death within the first few years of life, for which there are no proven general therapies. Mice lacking the complex I subunit, Ndufs4, develop a fatal progressive encephalopathy resembling Leigh syndrome and die at ≈60 d of age. We previously reported that continuously bre...

INTRODUCTION Skepticism exists about whether normobaric and hypobaric hypoxic exposures are equivalent. We have evaluated if physiological differences between the two environments would translate into actual differences in hypoxia symptoms. METHODS We exposed 20 subjects to 5-min 25,000-ft (7620-m) equivalent environments in an altitude chami ber and then in a ground-level portable reduced-ox...

A derivative of the beta-carboline alkaloid harmine — drug hydrochloride was studied for presence antihypoxic properties in models hypobaric hypoxia and normobaric with hypercapnia. It found that does not have a signifi cant compensatory effect test At same time, small doses (2.5 5 mg/kg) has activity test, which is expressed statistically increase life expectancy animals treated drug, compared...

Renal (peritubular) tissue hypoxia is a well-known physiological trigger for erythropoietin (EPO) production. We investigated the effect of rebound relative hypoxia after hyperoxia obtained under normo- and hyperbaric oxygen breathing conditions. A group of 16 healthy volunteers were investigated before and after a period of breathing 100% normobaric oxygen for 2 h and a period of breathing 100...

Previous research, although limited, suggests that both hypoxia and bed rest influence psychological responses by exaggerating negative psychological responses and attenuating positive emotions. The present study investigated the effect of a 21-day prolonged exposure to normobaric hypoxia and bed rest on affective responses and fatigue. Eleven healthy participants underwent three 21-day interve...

In the article, experiments were carried out on white mice normobaric, hemic and cytotoxic methods of acute hypoxia when administered orally at a dose 10; 30 60 mg/kg dry grape seed extract under normal conditions. According to results obtained, obtained showed high antihypoxic activity compared with control group reference drug mildronate.

OBJECTIVES Inter-individual variations in sea level performance after altitude training have been attributed, at least in part, to an inter-individual variability in hypoxia induced erythropoiesis. The aim of the present study was to examine whether the variability in the increase in total haemoglobin mass after training at moderate altitude could be predicted by the erythropoietin response aft...