objective(s): hypoxia is a serious challenge for treatment of solid tumors. this condition has been manifested to exert significant therapeutic effects on glioblastoma multiform or (who) astrocytoma grade iv. hypoxia contributes numerous changes in cellular mechanisms such as angiogenesis, metastasis and apoptosis evasion. furthermore, in molecular level, hypoxia can cause induction of dna brea...

introduction: pro-inflammatory chemokines and cytokines   such as mcp-1 and il6 can activate microglial cells that has found in some neuro-inflammatory disorders. hypoxia activates cerebral endothelial cells to release these pro-inflammatory mediators. we aimed to investigate the anti-hypoxic effects of different doses of some gabaergic agents. materials and methods: we randomly divided 150 mic...

Objective(s): Impairment of nerve cells of brain induced by hypoxia results in energy-deprivation and dysfunction, which accompanies with neurons apoptosis. Improving function of nerve cells is important for treating cerebral anoxia. This study aimed to investigate the role of Quercetin (Quer) in hypoxia-induced injury of pheochromocytoma (PC-12) cells. Materials and Methods: PC-12 cells were c...

mouth breathing might not always result in hypoxia, but can contribute to it. the aim of the present study was to determine the effect of mouth breathing on hypoxia. based on a pilot study, 323 patients with mouth breathing were selected. assessment of mouth breathing was based on clinical examination and questionnaires filled out by patients and their companions. the patients were also examine...

background : foreign body aspiration is a common medical emergency among children that can lead to lethal complications especially in neglected or misdiagnosed cases. case report: this article is a report of a 15-month-old child who aspirated food materials and after chocking crisis, she presented with unspecific respiratory symptoms and treated for respiratory tract infections. after five days...

due to advanced treatments in the field of heart disease, cyanotic heart disease patients have a greater chance of survival, and nowadays many of them live until adolescence or middle age. one of the signs of this disease is blood hypoxia, which has acute and chronic effects on the cns. in this paper the effect of chronic hypoxia on children affected by cyanotic congenital heart disease (chd) i...

the influence of dissolved oxygen concentration on gill histopathology of great sturgeon (huso huso) was evaluated in two weight classes (initial weight 280.9?49.2 g and 1217.9?138.1 g respectively). oxygen treatments included hypoxia (2-3 mg/l), normoxia (5-6 mg/l) and hyperoxia (9-10 mg/l). the fish were acclimated to experimental tanks for one week then randomly distributed into 9 tanks in e...

a periodic increase in blood pressure (bp) occurs during apneic episodes in patients with obstructive sleep apnea (osa). several factors including hypoxemia and an increase in heart rate (hr) were reported to be responsible for this increased bp. to examine the contribution of these two factors in increasing bp, 35 healthy male subjects (mean age±sd= 23.64±3.80) were studied in three experiment...

background: mesenchymal stem cells (mscs) are important candidates for msc-based cellular therapy. current paradigm states that mscs support local progenitor cells in damaged tissue through paracrine signaling. therefore, study of paracrine effects and secretome of mscs could lead to the appreciation of mechanisms and molecules associated with the therapeutic effects of these cells. this study ...