The simple boronated bases, e.g. cytosine, adenine and guanine, containing no sugar residues retained good pharmacological activity as hypolipidemic, anti-neoplastic and anti-inflammatory agents in mice at 8 mg/kg. Their activities were generally identical to their respective nucleoside derivatives. Interestingly the boronated acyclovir derivative was a very potent hypolipidemic agent achieving...

OBJECTIVE To review the efficacy and safety of fenofibrate in the management of hyperlipidemias. DATA SOURCES A MEDLINE search (1974-October 1998), Current Contents search, additional references from article bibliographies, and the package insert from the manufacturer were used to identify data for evaluation. Studies evaluating fenofibrate (peer-reviewed publications, package insert data) we...

Objective: Turmeric (Curcuma Longa Linn) is a medicinal plant that contains curcumin. There is a growing interest in using curcumin powder (CP) as feed additives for antioxidative and antimicrobial properties to improve human health. This study was conducted to determine the appropriate levels of CP on blood parameters, immunity, and histology of jejunum in hens. Materials and Methods: A total ...

RMI 14, 514 ([5-tetradecycloxy]-2-furancarboxylic acid) represents a new class of hypolipidemic agents which cause unusual ultrastructural changes in liver of male rats and in selected peroxisomal enzymes in liver and kidney of both sexes. Among the principal ultrastructural changes in peroxisomes of male rat liver were (a) cavitation and compartmentalization of the matrix, often giving the app...

The dried marine microalga Dunaliella tertiolecta was fed to weaning albino rats for 12 days as the sole protein source at a protein level of 12% protein from casein. Plasma cholesterol, triglycerides, and CPK levels were significantly lower in animals given the microalgal diet than in the control group with values 19.12 %, 45.80%, and 43.90% lower, respectively. These results suggest that the ...

In atherogenic diet induced hyperlipidemic model, the rats receiving treatment with the aqueous extract of the leaves of E. prostrata showed significant reduction in total cholesterol, triglyceride, total protein and elevation in high density lipoprotein cholesterol. The aqueous extract of E. prostrata was found to possess significant hypolipidemic activity. The results also suggest that E. pro...

The fruits of Persea Americana Mill., commonly known as Avocado, are traditionally consumed for various health benefits including weight reduction. Here, we studied the effect of hydroalcoholic fruit extract of Persea americana (HAEPA) on high fat diet (HFD) induced obesity in rats. Obesity was induced in male Sprague Dawley rats by feeding HFD for 14 wk. The hypolipidemic effect was evaluated ...

The present study was carried out to evaluate the hypoglycemic and hypolipidemic activity of ethyl aceteta extract flower extract of Alangium salviifolium (Linn. F). in STZ induced diabetic rats. Diabetes was induced into albino Wistar rats by intraperitonial administration of STZ. Blood samples were collected from overnight fasted normal and diabetic rats on 1th, 5th, 10th and 15th days of tre...