Diabetes mellitus (DM) is an important global public health problem. Despite the availability of drug therapy, patients have continued using plants with anti-diabetic properties as alternative treatments for diabetes. Cucurbita ficifolia Bouché (C. ficifolia) is a plant cultivated in Mexico for its edible fruit that is medicinally used to control type 2 DM (T2D). The hypoglycemic effect of C. f...

The rhizome of Anemarrhena asphodeloides is used as food and traditional Chinese medicine for its hypoglycemic effect. The aim of this study was to investigate the isolation, purification and hypoglycemic activity of Anemaran as the active component. The influence factors (isolation duration, ratio of residuals to water and extracting times) during the isolation process were evaluated. The opti...

Diabetes mellitus is one of the most common endocrine diseases. Due to its complications, it caused significant mortality. Insulin and oral antidiabetic drugs were associated with many side effects. The search for more effective safer hypoglycemic agents important areas investigation. pharmacological investigations revealed that several medicinal plants showed effects by mechanisms. current rev...

BACKGROUND The active components of Gardenia (Gardenia jasminoides Ellis, GJ) exhibit a hypoglycemic effect by improving insulin secretion and lowering plasma lipids. In the present study, we fed a water extract of gardenia to steroid-induced insulin-resistant (SIIR) rats and observed changes in signaling proteins in order to elucidate the mechanisms of the insulin-sensitizing effect of GJ and ...

There is some report about the hypoglycemic effect of Juglans rejia L. leaf in alloxan induced diabetic rats and hypoglycemic effect of its fruit peel administered intra peritoneally. Thirty male Wistar rats divided into five groups, to evaluate the hypoglycemic and pancreas β-cells regenerative effects of oral methanolic extracts of leaf and fruit peel of walnut. Rats were made diabetic by int...

the hypoglycemic effect of ethanolic extract of casearia esculenta was investigated on alloxan induced diabetic rats. the blood glucose levels were measured at 0, 1, 2 and 3 h after the treatment. the ethanolic extract of c. esculenta (250 mg/kg) reduced the blood glucose of normal rat from 85.50±1.22 to 64.67±3.27 mg/dl, 3 h after oral administration of the extract (p<0.05). it also significan...

The effect of hypoglycemia on the progression of atherosclerosis in patients with type 2 diabetes mellitus (T2DM) remains largely unknown. This is a post hoc analysis of a randomized trial to investigate the relationship between hypoglycemic episodes and changes in carotid intima-media thickness (IMT). Among 274 study subjects, 104 patients experienced hypoglycemic episodes. Increases in the me...

Indigenous plants such as Ocimum Sancium, Aegle marmelos, Azadiracta indica, and Murraya koenigii decreased the blood sugar of streptozotocin diabetic rabbits. The most effective drug Aegle marmelos in different solvents showed different rate of hypoglycemic action. On feeding streptozotocin to diabetic rabbits for a period of 3 months aegle marmelos showed remarkable hypoglycemic action.

Mulberry is one of the Chinese traditional medicines. But few studies focused on the hypoglycemic effect of Mulberry seed and the possible mechanisms. We identified that mulberry seed is rich in DNJ, the content of which is 0.6015%. Both mulberry seeds powder and its aqueous extract were used to detect the hypoglycemic effect of mulberry seeds. The results indicated that mulberry seeds powder c...