1.0 Introduction 1.1 Purpose 1.2 Causes of excessive sleepiness 2.0 Background 3.0 Methods 3.1 Literature search strategy 3.2 Evidence review 4.0 Results 4.1 Treatment of hypersomnia due to narcolepsy with or without cataplexy 4.1.1 Medications 4.1.1.1 Amphetamine, methamphetamine, dextroamphetamine methylphenidate, and related preparations 4.1.1.2 Modafinil and armodafinil 4.1.1.3 Sodium oxyba...

OBJECTIVE In this study, we used a strict definition of hypersomnia and tested if the association between overeating-hypersomnia remained positive and significant. Hypersomnia was present if the total sleep time was close to 10h per day or was at least 2h longer than in normothymic periods. METHODS Cross-sectional study using the adult general population of California and New York. The sample...

We report on a stroke patient who showed recovery of hypersomnia concurrent with the recovery of an injured ascending reticular activating system (ARAS), which was demonstrated by diffusion tensor tractography (DTT).A 70-year-old female patient underwent coiling of the left ruptured posterior communicating artery after subarachnoid hemorrhage and both extraventricular drainage for management of...

BACKGROUND Bilateral paramedian thalamic infarctions (BPTIs) due to artery of Percheron occlusion are known to cause hypersomnia. However, the role of hypocretin-1, a wake-promoting peptide that is located at the lateral hypothalamus, in hypersomnia in these patients remains unclear. METHODS To clarify the role of hypocretin-1 in hypersomnia in patients with BPTIs, hypocretin-1 levels in the ...

Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam; Department of Neurology, Seoul National University College of Medicine, Seoul, Korea Wilson’s disease shows considerably various symptoms that sometimes timely diagnosis is delayed when patient shows vague clinical presentation. We present a female patient whose initial symptom was hypersomnia and severe fatigue...

BACKGROUND Though poorly defined, hypersomnia is associated with negative health outcomes and new-onset and recurrence of psychiatric illness. Lack of definition impedes generalizability across studies. The present research clarifies hypersomnia diagnoses in bipolar disorder by exploring possible subgroups and their relationship to prospective sleep data and relapse into mood episodes. METHOD...

When sleepiness is excessive, undesirable, inappropriate or unexplained, it often indicates a clinical disorder that is generically termed hypersomnia. One of the leading causes of hypersomnia is sleep apnea. We present the case of a 44-year-old woman with a history of bipolar spectrum disorder and epilepsy who initially showed evidence of hypersomnia. The hypersomnia settled with changes to he...

Many patients report symptoms of hypersomnia with mostly excessive daytime sleepiness. According to the second edition of the International Classification of Sleep Disorders (ICSD2), hypersomnias of central origin are categorized as narcolepsy and idiopathic hypersomnia (IH).1 And narcolepsy can be divided into two categories based on the existence of cataplexy as narcolepsy with cataplexy (NTC...

A case of Kleine-Levin syndrome, with chronic severe periodic hypersomnia is described in a 17-year-old female. The first episode started when she was 15 years old. The episodes were characterized by periodic hypersomnia accompanied by hyperphagia, lasting 5 days, and repeating at 28 to 60 day intervals. The severity of hypersomnia prevented her from attending school activities. Outside the hyp...