Thyrotoxic periodic paralysis (TPP) attacks are characterized as recurrent, transient episodes of muscle weakness that range from mild weakness to complete flaccid paralysis. Episodes of weakness are accompanied by hypokalemia, which left untreated can lead to life-threatening arrhythmias (6). In this case study, we followed a patient's potassium levels analyzing how they correlate with electro...

Thyrotoxic Periodic Paralysis (TPP) is a rare and life threatening condition commonly occurring in young Asian males. It is characterized by acute paralytic attacks and hypokalemia in association with thyrotoxicosis. Serum potassium levels may be normal in rare cases of TPP. The diagnosis of normokalemic TPP may be overlooked and/or delayed in most cases. Here, we describe a 32-year-old Iranian...

Familial hyperkalemic periodic paralysis is an autosomal-dominant channelopathy characterized by reversible paralysis associated with episodic hyperkalemia. Mutations in the skeletal muscle voltage-gated sodium channel gene (SCN4A) have been reported to be responsible for this disorder. Paramyotonia congenita is also caused by mutations in the SCN4A gene. Here, we report the case of a 17-year-o...

9. Fontaine B, Khurana TS, Hoffman EP et al. Hyperkalemic periodic paralysis and the adult muscle sodium channel alpha-subunit gene. Science 1990; 250: 1000–1002 10. Ptacek LJ, George AL Jr, Griggs RC et al. Identification of a mutation in the gene causing hyperkalemic periodic paralysis. Cell 1991; 67: 1021–1027 11. Rojas CV, Wang JZ, Schwartz LS et al. A Met-to-Val mutation in the skeletal mu...

An 8-year-old boy with familial hypokalemic periodic paralysis is described. Twenty eight cases of periodic paralysis under 15 years of age were collected from the Japanese literature and reviewed. Serum potassium concentrations during an attack of paralysis were recorded in 27 cases including our case: 20 cases were hypokalemic, 4 were normokalemic and 3 were hyperkalemic. Hypokalemic periodic...

From ‡The Miami Project to Cure Paralysis, Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida 33136, the **Neuroscience Program, Miller School of Medicine, University of Miami, Miami, Florida 33136, the ‡‡Laboratory of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China, and the §Department of Physiology, Medical College of ...

Primary hypokalemic periodic paralysis (PHPP) is a rare entity first described by Shakanowitch in 1882. Only a few cases of PHPP have been reported in Indian literature in adults(l). In children hypokalemic paralysis secondary to gastroenteritis and chronic renal disease is much more common than primary disease(2). We hereby report a case of PHPP in a child, successfully managed with acetazolam...

BACKGROUND Primary periodic paralyses are rare inherited muscle diseases characterised by episodes of flaccid weakness affecting one or more limbs, lasting several hours to several days, caused by mutations in skeletal muscle channel genes. OBJECTIVES The objective of this review was to systematically review treatment of periodic paralyses. SEARCH STRATEGY We searched the Cochrane Neuromusc...