Nonhealing wounds represent a problem involving inadequate oxygenation of the tissues that can lead to hypoxic injury. Hyperbaric oxygen therapy can be used as an adjunctive therapy for compromised grafts and flaps that have failed to show improvement with standard wound therapy and offer additional physiologic benefits in the reversal of wound hypoxia and hypoperfusion. A literature review con...

The objective of this retrospective analysis was to determine the reliability of transcutaneous oxygen tension measurement (TcPO2) in predicting outcomes of diabetics who underwent hyperbaric oxygen therapy for lower extremity wounds. Six hyperbaric facilities provided TcPO2 data under several possible conditions: breathing air, breathing oxygen at sea level, and breathing oxygen in the chamber...

PURPOSE This study was to observe the clinical effects of hyperbaric oxygen therapy combined with supragingival and subgingival scaling therapy on periodontitis. METHODS The patients with periodontitis were divided randomly into 3 groups, the supragingival and subgingival scaling therapy group, the hyperbaric oxygen therapy group, the hyperbaric oxygen combined with supragingival and subgingi...

The foot ulcer is one of most common and devastating complications of diabetes and is associated with considerable morbidity and mortality. The major causes of these ulcers are ischemia/hypoxia, neuropathy, and infection, and they often coexist. Despite conventional therapy including revascularization procedures when appropriate, three situations lead frequently to amputation: persistent critic...

Hyperbaric oxygen therapy is a treatment for wounds in any location and of any duration that has been misunderstood for 353 years. Since 2008 it has been applied to the persistent post-concussion syndrome of mild traumatic brain injury by civilian and later military researchers with apparent conflicting results. The civilian studies are positive and the military-funded studies are a mixture of ...

UNLABELLED Many healthcare providers may overlook or even be unaware of most drug-to-drug interactions. Recognizing the existence of drug interactions with the use of hyperbaric oxygen can empower a clinician with knowledge to avoid dangerous interactions that may result in hazardous, negative patient outcomes. Hyperbaric oxygen therapy (HBOT) can reduce the efficiency of certain drugs or make...

Hyperbaric oxygen therapy can be used as an adjunct to standard wound care in the treatment of diabetic patients with foot ulcers. We undertook a prospective, randomized investigation of the use of hyperbaric oxygen therapy versus standard therapy for the treatment of foot ulcers in diabetic patients. A number of demographic variables were analyzed in regard to wound healing. We noted that foot...

Background Hyperbaric oxygen therapy is increasingly used in adjuvant therapies to treat neuropathic pain. However, the specific targets of hyperbaric oxygen treatment in neuropathic pain remain unclear. Recently, we found that hyperbaric oxygen therapy produces an antinociceptive response via the kindlin-1/wnt-10a signaling pathway in a chronic pain injury model in rats. Methods The rats rec...

Many healthcare providers may overlook or even be unaware of most drug-to-drug interactions. Recognizing the existence of drug interactions with the use of hyperbaric oxygen can empower a clinician with knowledge to avoid dangerous interactions that may result in hazardous, negative patient outcomes. Hyperbaric oxygen therapy (HBOT) can reduce the efficiency of certain drugs or make drug therap...

OBJECTIVES The purpose is to study the effects of hyperbaric oxygen therapy and autologous platelet concentrates in healing the fibula bone of rabbits after induced fractures. METHODS A total of 128 male New Zealand albino rabbits, between 6-8 months old, were subjected to a total osteotomy of the proximal portion of the right fibula. After surgery, the animals were divided into four groups (...