نتایج جستجو برای: hynic

تعداد نتایج: 217  

Journal: :Cancer biotherapy & radiopharmaceuticals 2006
Ekaterina Dadachova Tiffany Moadel Andrew D Schweitzer Ruth A Bryan Tong Zhang Lisa Mints Ekaterina Revskaya Xianchuan Huang Geraldina Ortiz Jerome S Nosanchuk Joshua D Nosanchuk Arturo Casadevall

The incidence of melanoma is rising, and therapeutic options for metastatic melanoma are limited. We report the results of experimental melanoma therapy with 188-Rhenium-labeled melanin-binding decapeptide ((188)RE-HYNIC-4B4) and a comprehensive safety evaluation of this treatment. (188)RE-HYNIC- 4B4 bound only to nonviable eumelanotic MNT1 and pheomelanotic SK-28-MEL human melanoma cells in vi...

Journal: :The Prostate 2017
Ismaheel O Lawal Alfred O Ankrah Neo P Mokgoro Mariza Vorster Alex Maes Mike M Sathekge

BACKGROUND Emerging data from published studies are demonstrating the superiority of Ga-68 PSMA PET/CT imaging in prostate cancer. However, the low yield of the Ge-68/Ga-68 from which Gallium-68 is obtained and fewer installed PET/CT systems compared to the SPECT imaging systems may limit its availability. We, therefore, evaluated in a head-to-head comparison, the diagnostic sensitivity of Ga-6...

2014
Yong Yang Shundong Ji Shuang Liu

This study sought to evaluate the impact of multiple negative charges on blood clearance kinetics and biodistribution properties of (99m)Tc-labeled RGD peptide dimers. Bioconjugates HYNIC-P6G-RGD2 and HYNIC-P6D-RGD2 were prepared by reacting P6G-RGD2 and P6D-RGD2, respectively, with excess HYNIC-OSu in the presence of diisopropylethylamine. Their IC50 values were determined to be 31 ± 5 and 41 ...

2013
Kazuma Ogawa Katsuichi Ohtsuki Tomomi Shibata Miho Aoki Morio Nakayama Yoji Kitamura Masahiro Ono Masashi Ueda Tomoki Doue Masahisa Onoguchi Kazuhiro Shiba Akira Odani

(99m)Tc-HYNIC-annexin A5 can be considered as a benchmark in the field of apoptosis imaging. However, (99m)Tc-HYNIC-annexin A5 has characteristics of high uptake and long retention in non-target tissues such as kidney and liver. To minimize this problem, we developed a novel (99m)Tc-labeled annexin A5 using a bis(hydroxamamide) derivative [C3(BHam)2] as a bifunctional chelating agent, and evalu...

Journal: :Endokrynologia Polska 2006
Rafał Czepczyński Jerzy Kosowicz Katarzyna Ziemnicka Renata Mikołajczak Maria Gryczyńska Jerzy Sowiński

INTRODUCTION Recently a new somatostatin analogue labelled with (99m)Tc ((99m)Tc-HYNIC-TOC) has been synthetized. Aim of this study was to evaluate the utility of (99m)Tc-HYNIC-TOC in the radionuclide imaging in patients with medullary thyroid carcinoma (MTC). MATERIAL AND METHODS 30 patients with MTC aged 22-83 years in different stages of the disease were investigated. In 6 patients (group ...

2013
Emel Koçyiğit Deveci Meltem Ocak Murat Fani Bozkurt Selcan Türker Levent Kabasakal Ömer Uğur

OBJECTIVE The aim of this study was to assess the diagnostic efficiency of (99m)Tc-EDDA/HYNIC-Octreotate in comparison with (111)Inpentetrotide scintigraphy in the detection of neuroendocrine tumors. This study also evaluates the impact of SPECT-CT hybrid imaging on somatostatin receptor scintigraphy (SRS) interpretation and clinical management of these tumors. METHODS Fourteen patients were ...

Journal: :Molecules 2016
Zhide Guo Mengna Gao Manli Song Changrong Shi Pu Zhang Duo Xu Linyi You Rongqiang Zhuang Xinhui Su Ting Liu Jin Du Xianzhong Zhang

The folate receptor (FR) is overexpressed in a wide variety of human tumors. In our study, the multimeric concept was used to synthesize a dimeric folate derivative via a click reaction. The novel folate derivative (HYNIC-D₁-FA₂) was radiolabeled with (99m)Tc using tricine and trisodium triphenylphosphine-3,3',3″-trisulfonate (TPPTS) as coligands ((99m)Tc-HYNIC-D₁-FA₂) and its in vitro physicoc...

Journal: :Journal of Experimental & Clinical Cancer Research : CR 2009
Ming-fang Guo Yaqing Zhao Rong Tian Lin Li Leiming Guo Feng Xu Yong-mei Liu Yong-bo He Sen Bai Jin Wang

BACKGROUND Apoptosis is a major mode of hematological tumor death after radiation. Early detection of apoptosis may be beneficial for cancer adaptive treatment. 99mTc-HYNIC-annexinV has been reported as a promising agent for in vivo apoptosis imaging. The purpose of this study is to evaluate the feasibility of in vivo99mTc-HYNIC-annexinV imaging of radiation- induced apoptosis, and to investiga...

2017
Zunyu Xiao Yan Song Wang Kai Xilin Sun Baozhong Shen

Tyrosine kinase inhibitors (EGFR-TKIs) targeting the epidermal growth factor receptor (EGFR) have been used in non-small cell lung carcinoma (NSCLC) for years with promising results, in particular in patients with activating mutations in the EGFR kinase domain (exon 19 E746-A750 deletion or exon 21 L858R point mutation). However, despite their great success in the clinic, a significant number o...

Journal: :PloS one 2015
Kaiyin Min Bin Ji Min Zhao Tiefeng Ji Bin Chen Xuedong Fang Qingjie Ma

Breast cancer is one of the most frequent and aggressive primary tumors among women of all races. Matrix metalloproteinase (MMPs), a family of zinc- and calcium-dependent secreted or membrane anchored endopeptidases, is overexpressed in varieties of diseases including breast cancer. Therefore, noninvasive visualization and quantification of MMP in vivo are of great interest in basic research an...

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