The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of Cyproheptadine Hydrochloride (CPH) which is a sedating antihistamine with antimuscarinic, serotonin-antagonist, and calcium-channel blocking action. Buccal films were made with Hydroxy propylcellulose (HPC EF) and Hydroxy Propyl Methyl Cellulose (HPMC E15) as mucoadhesive polymers. Permeation of CPH ...

Poor bioavailability is one of the most significant problems in delivery ocular drug system. Ophthalmic ointments, solutions and suspensions are frequently used dosage forms to treat disease, their effectiveness as a compromised by several limitations that lead poor bioavailability. In situ gel promising strategy improve drugs. The purpose this review discuss formulation characterization gel. T...

The advantage of administering a single dose of a drug that is released over an extended period of time instead of numerous doses is now a day’s area of interest for formulation scientists in Pharmaceutical industry. There are several advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance due to less frequent drug administration, maximum ut...

The aim of the present study was to develop a new theophylline hard gelatin capsule drug delivery formulation. The formulation have been prepared to enhance its dissolution which could provide better oral absorption of theophylline. Therefore, the effects of the component nature and their proportion in the release rate were investigated. Extended release capsules of theophylline were prepared b...

The present investigation was undertaken with an objective of formulating modified release (MR) matrix tablets of Oxcarbazepine (OXC) an anti-epileptic drug, based on cellulose ether polymers like Hydroxy Propyl Methyl Cellulose (HPMC K4M and LVCR 100) and Hydroxy Propyl Cellulose (HPC JF) as drug release retardants to overcome poor patient compliance and exposure to high doses associated with ...

The use of hydrophilic polymers from natural origin. Especially the polysaccharides have been focus current research activity in design matrix device due to their non toxic, biocompatible, biodegradable nature and broad regulatory acceptance. A large number such as Carboxymethyl starch, Xanthan gum, Hydroxy propyl methyl cellulose (HPMC), Sodium Alginate etc, used matrices investigate release b...

Bay leaf (Syzygium polyanthum (Wight.) contains polyphenolic compounds that are beneficial in the treatment of hypercholesterolemia by reducing Low Density Lipoprotein (LDL) levels. The dosage form mucoadhesive microgranules is able to prolong active substance contact time with mucosa give better therapeutic effect. This study aims make bay extract different polymers Hydroxy Propyl Methyl Cellu...

The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of Ondansetron Hydrochloride (OND) which is used for nausea and vomiting associated with cancer chemotherapy and radiotherapy. Permeation of OND was calculated ex vivo using porcine buccal membrane. Buccal films were developed by solvent-casting technique using Hydroxy Propyl Methyl Cellulose(HPMC E15) ...

The purpose of our study was to achieve the gastro-retentive delivery Clarithromycin by producing floating pellets get a better therapeutic effect against gastrointestinal ulcers mostly caused Hedyotis pylori. Thereby were prepared utilizing blending polymers such as Sodium (Na) Alginate and Hydroxy Propyl Methyl Cellulose (HPMCK4M & HPMC K100LV). HPMC-alginate blend containing produced hyd...