The objective of the present study was to develop ofloxacin medicated dental gels for extended period of time. The clinical evaluation of ofloxacin was carried out to determine the efficacy in the treatment of periodontitis. The ofloxacin medicated dental gels prepared with different hydrophilic polymers methyl cellulose, hydroxy propyl methyl cellulose, hydroxy propyl cellulose and hydroxy eth...

A study has been carried out to assess the potential use of pectin in combination with two added hydrocolloids, i.e., hydroxy-propyl-methyl cellulose and hydroxyethyl cellulose in varied concentrations and coated with ethyl cellulose and cellulose acetate phthalate. The results of in vitro drug release showed that the matrix tablets prepared with pectin, hydroxy ethyl cellulose (20 percent) whe...

Bi-layered [1] tablet refers to tablet which contain subunits. In bi-layer [2] tablets, one layer tablet provides immediate release and the other layer acts as sustained release. Sumatriptan is a new class of anti-migraine [3] drugs that selectively activate 5-HT1B/1D receptors and are called triptans. Our objective is to formulate and evaluate the bi-layer tablets of sumatriptan succinate of d...

A baby full term born of LSCS to a otherwise healthy mother was referred for ophthalmology department. On ophthalmological torch light examination, the patient had equal upper and lower lid bilateral ectropion. There missing eye lashes noted. The anterior segment evaluation found be within normal limit without evidence corneal opacities. Lamellar ichthyosis termed as Collodion is infrequent dis...

The present investigation was undertaken with an objective of formulating modified release (MR) matrix tablets of Oxcarbazepine (OXC) an anti-epileptic drug, based on cellulose ether polymers like Hydroxy Propyl Methyl Cellulose (HPMC K4M and LVCR 100) and Hydroxy Propyl Cellulose (HPC JF) as drug release retardants to overcome poor patient compliance and exposure to high doses associated with ...

Edible films and coatings in foods can be used to increase shelf-life and improve organoleptic characteristics of foods by avoiding deterioration of food components and therefore promoting preservation of the final product. This study is the first to investigate the use of different size fillers for the purpose of preparing edible composite films with fillers < 1.0 microm in size. For this purp...

in recent years, great efforts have been devoted to the design of drug delivery systems. many polymeric excipients have been studied in order to make drug release fit the desired profiles. the aim of this work was to design a theophylline oral suspension, as sustained release pharmaceutical preparation in order to decrease the plasma level fluctuations and adverse effects of theophylline. micro...

The main aim of this study was preparation and evaluation of extended - release system ofthe anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general propertiessimilar to those of diazepam. Our studies focused on development of extended drug deliverysystem based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent andPolyvinylpyrrolidone (PVP k30) as binder us...

The goal of this study was to design and evaluate extended - release system of the hypnotic agent, Zolpidemtartrate usefulness for the treatment of insomnia. The half-life of this drug is about 1.9 - 3 hours that indicatingit a candidate for the extended release formulation. Our investigation relates to development of extendeddrug delivery system based on Hydroxy propyl methyl cellulose (HPMCK4...