Abstract Natural free fatty acids show inhibitory effects on α-glucosidase and can hence have potential applications in diabetes treatment. This study indicated that the effect of showed a significant negative correlation with affinity energy (− 0.87) melting point 0.88). Guided by this relationship, two promotion strategies hydration esterification were put forward to increase α-glucosidase. T...

Poly(α-hydroxy acids), as a family of biodegradable polyesters, are valuable materials due to their broad applications in packaging, agriculture, and biomedical engineering. Herein we highlight explore recent advances catalysts controlled ring-opening polymerization O-carboxyanhydrides towards functionalized poly(α-hydroxy especially metal catalyst-mediated polymerization. Limitations current s...

To obtain information on the concentration and spectrum of bile acids in human cecal content, samples were obtained from 19 persons who had died an unnatural death from causes such as trauma, homicide, suicide, or drug overdose. Bile acid concentration was measured via an enzymatic assay for 3alpha-hydroxy bile acids; bile acid classes were determined by electrospray ionization mass spectrometr...

Research in my laboratory focuses on developing new microbial processes for adding functionality groups to plant lipids or their component fatty acids to produce value-added food and industrial products. The goal is to develop new products from surplus soybean oil or its component fatty acids through bioprocesses. Oxygenated fatty acids such as hydroxy-, keto-, epoxy-, and cyclic fatty acids ar...

Seven phenolic acids and many nonphenolic organic acids, including large amounts of meta-hydroxy (3-hydroxy) benzoic acid and 3-hydroxy-1,5-benzene-dicarboxylic acid, were obtained from the organic polymer of the Murchison C2 chondrite upon oxidation with alkaline cupric oxide. The phenolic acids apparently were derived from phenolic ethers in the polymer, which in turn probably were formed fro...

The main fatty acids present in lipopolysaccharides from Bacteroides fragilis NCTC 9343 were identified as 13-methyl-tetradecanoic, D-3-hydroxypentadecanoic, D-3-hydroxyhexadecanoic, D-3-hydroxy-15-methyl-hexadecanoic, and D-3-hydroxyheptadecanoic acids. Of these, 13-methyl-tetradecanoic acid is exclusively ester bound, and 3-hydroxy-15-methyl-hexadecanoic acid is exclusively involved in amide ...

We previously reported that 3-hydroxy fatty acids promoted the survival of cryptococcal cells when acted upon by amoebae. To expand on this, the current study sought to explain how these molecules may protect cells. Our data suggest that 3-hydroxy fatty acids may subvert the internalization of cryptococcal cells via suppression of the levels of a fetuin A-like amoebal protein, which may be impo...

Catalysis of the acylation aniline with 3-­hydroxy-2-naphthoic, 1-hydroxy-2-naphthoic, 2-hydroxy-1-naphthoic and 1-hydroxy-4-naphthoic acids by phosphorus P(III) silicon Si(IV) compounds leads to formation anilides corresponding hydroxy­naphthoic under mild conditions (ortho-xylene, 146.5–147 °C) in almost quantitative yield.
 Among trichloride tribromide; phosphorous, 1-hydroxyethyli­de­n...