Comb-shaped amphiphilic polymers are rapidly emerging as an alternative approach to amphiphilic block copolymers for hydrophobic drug solubilization. These polymers consist of a homopolymer or copolymer backbone to which hydrophobic and hydrophilic pendant groups can be grafted resulting in a comb-like architecture. The hydrophobic pendants may consist of homopolymers, copolymers and other low-...

A dissipative particle dynamics (DPD) simulation is performed to investigate the spontaneous onion shape vesicle formation and fusion of A6(B2)3 type comb-like block copolymers with a semiflexible hydrophobic backbone. Our results show that comb-like block copolymers of A6(B2)3 type may be a good candidate for onion shape vesicle formation. The spontaneous fusion dynamics between the onion shap...

A family of amphiphilic, heterograft copolymers containing hydrophilic, hydrophobic, and supramolecular units based on Jeffamine M-1000, dodecylamine, and benzene-1,3,5-tricarboxamide (BTA) motifs, respectively, was prepared via a postfunctionalization approach. The folding of the copolymers in water into nanometer-sized particles was analyzed by a combination of dynamic and static light scatte...

Binary nylon-3 copolymers containing cationic and hydrophobic subunits can mimic the biological properties of host-defense peptides, but relationships between composition and activity are not yet well understood for these materials. Hydrophobic subunits in previously studied examples have been limited mostly to cycloalkane-derived structures, with cyclohexyl proving to be particularly promising...

Bonding of hydrophobic plastic materials to wood to create new wood-plastic (polystyrene) materials with improved mechanical and physical properties that incorporate the desirable features of each constituent is difficult to achieve, This is due to poor interfacial adhesion between the wood and polystyrene components because of their inherent incompatibility. New, well-defined, tailored cellulo...

The polydispersity effect of amphiphilic AB diblock copolymers on the self-assembled morphologies in solution has been investigated by the real-space implementation of self-consistent field theory (SCFT) in two dimensions (2D). The polydispersity is artificially obtained by mixing binary diblock copolymers where the hydrophilic or hydrophobic blocks are composed of two different lengths while t...

We report an extensive simulation study on the spontaneous formation of complex micelles from coilrod-coil amphiphilic triblock copolymers in dilute solution resulting from solvent selectivity. The amphiphilic molecule is built from one hydrophilic block on each side and a hydrophobic block in the middle. The rigidity of the rod block is introduced by adding a bond-bending potential of the angl...

This chapter is a summary of our work on the design of block copolymer micellar systems with improved solubilization capacity for poorly soluble aromatic drugs. The copolymers of interest are block copoly(oxyalkylene)s with linear dior triblock architecture which combine hydrophilic poly(ethylene oxide) with hydrophobic blocks formed from poly(propylene oxide), poly(1,2-butylene oxide), poly(st...

The self-organization of amphiphilic block copolymers in water strongly depends on their molecular structure, particularly their hydrophilic–hydrophobic balance. This study proposes tuning the amphiphilicity of block copolymers by a click strategy. This work prepares novel amphiphilic block-graft PCL-b-(PaN3CL-g-PBA) copolymers that comprise poly(e-caprolactone) (PCL) as the hydrophobic segment...

The incorporation of neutral hydrophilic monomer units in the hydrophobic B blocks BAB copolymers produces transient networks exhibiting a thermoresponsive behavior with maximum viscosity water.