Periodate-oxidized ppp(A2'p)3A was coupled in high yield to an acyl hydrazide derivative of bovine serum albumin and the conjugate was used to immunize rabbits. Several potent and specific antisera were obtained, and one was tested extensively. Fifty per cent of the bound probe ppp(A2'p)3A3'[32P]pCp was displaced by compounds containing the moiety -pA2'pA-at concentrations of 20-60 nM and by co...

There has been considerable interest in the development of novel compounds with anticonvulsant, antioxidant, antibacterial, and antifungal activities. The present study explores antimicrobial activity some new arylidene hydrazide derivatives correlates effect on potency by varying substituents part arylidine hydrazide. Hydrazones possessing an azomethine–NHN=CH- proton constitute important clas...

In this study, one novel N-pyrrolyl carboxylic acid (3), the corresponding hydrazide (5), and four new hydrazide-hydrazones (5a-d) bearing electron donating moieties were designed, synthesized, fully elucidated by 1H NMR, FT-IR, HRMS. The produced in five steps, which optimized applying microwave heating. microwave-assisted synthesis significantly decreased reaction times increased yields of ti...

In the title compound, C(8)H(9)BrN(2)O, the 1-bromo-4-methyl-benzene group and the formic hydrazide moiety [r.m.s. deviations of 0.0129 and 0.0038 Å] are oriented at a dihedral angle of 80.66 (11)°. In the crystal, mol-ecules are linked via strong N-H⋯O hydrogen bonds, leading to the formation of chains in the [010] direction. These chains are linked via weaker N-H⋯N and N-H⋯O hydrogen bonds, w...

A new class of quinoline derivatives containing pyrazoline-5-one and pyrazole moiety (3a-j and 4a-j) have been synthesized by condensation of various oxobutyrates/pentane-2,4-dione derivatives with 8-quinolinoxyacetic acid hydrazide. Elemental analysis, IR, H NMR and mass spectral data support the structures of the newly synthesized compounds. The synthesized compounds have been evaluated for t...

In the crystal structure of the title compound, C8H8N4O5·H2O, the organic and lattice water mol-ecules are linked together via N-H⋯O and O-H⋯O hydrogen bonds. A C-H⋯O inter-action is also observed between the organic mol-ecules. These hydrogen bonds and inter-actions lead to the formation of a three-dimensional network. An intra-molecular N-H⋯O hydrogen bond also occurs. The dihedral angle betw...

Novel derivative of isoniazid containing 1,3,4-oxadiazole pharmacophore has been synthesized. The chemical structure the compound was characterized and confirmed by using FT-IR 1H-NMR spectroscopy.
 
 desired tested against gram-positive gram-negative bacteria agar well-diffusion technique for their ability as antibacterial agent showed good activity bacteria. In addition, ADME evalua...

The rise in drug-resistant strains of Mycobacterium tuberculosis is a major threat to human health and highlights the need for new therapeutic strategies. In this study, we have assessed whether high-affinity iron chelators of the pyridoxal isonicotinoyl hydrazone (PIH) class can restrict the growth of clinically significant mycobacteria. Screening a library of PIH derivatives revealed that one...