Hydantoin derivatives are commonly used anticonvulsants. In general, they effective for partial-onset seizures and tonic-clonic seizures, but not absence seizures. Phenytoin is the most important drug in this group, other drugs, ethotoin, mephenytoin, also to treat epilepsy. Prodrugs such as have been created. some cases of trigeminal neuralgia related neuralgia. arrhythmias. Hydantoins or glyc...

The development of new methods for linking sugars to heterocycles and peptides is an attractive area of research because glyco-conjugates play important roles in biology and medicine and are indispensable tools for probing several processes. Herein we report a one-pot, three-component sequential procedure for the synthesis of a novel class of glyco-conjugates, i.e. glyco-hydantoin conjugates, i...

The Red Sea sponge Hemimycale arabica afforded the known (Z)-5-(4-hydroxybenzylidene)-hydantoin (1), (R)-5-(4-hydroxybenzyl)hydantoin (2), and (Z)-5-((6-bromo-1H-indol-3-yl)methylene)-hydantoin (3). The natural phenylmethylene hydantoin (PMH) 1 and the synthetic (Z)-5-(4-(ethylthio)benzylidene)-hydantoin (4) showed potent in vitro anti-growth and anti-invasive properties against PC-3M prostate ...

Synthesis routes to diphenyl hydantoin derivatives in the presence of benzils; 4,4-dimethylbenzil , 4-methylbenzil 4,4-bromobenzil 4-dimethylaminbenzoin and 4-amin-4-nitrobenzoin ure- give condensation benzil urea allowed by benzylic rearrangement.

In the title compound, C(15)H(17)ClN(2)O(4)S, the atoms in the hydantoin ring are coplanar (r.m.s. deviation = 0.006 Å). The crystal structure is stabilized by inter-molecular N-H⋯O hydrogen bonds which link the mol-ecules into centrosymmetric dimers. The dihedral angle subtended by the 4-chloro-phenyl group with the plane passing through the hydantoin unit is 82.98 (4)°. The cyclo-hexyl ring a...

In the title compound, C(10)H(9)FN(2)O(2), the dihedral angle between the hydantoin unit and the benzene ring is 65.55 (5)°. The atoms in the hydantoin ring are coplanar, with a mean deviation of 0.015 Å and a maximum deviation of 0.075 (2) Å for one carbonyl O atom. N-H⋯O hydrogen bonds link the mol-ecules into one-dimensional chains, with one carbonyl group acting as a bifurcated acceptor and...

BACKGROUND/AIM Neurofibromatosis 1-Noonan syndrome (NFNS) presents combined characteristics of both autosomal dominant disorders: NF1 and Noonan syndrome (NS). The genes causing NF1 and NS are located on different chromosomes, making it uncertain whether NFNS is a separate entity as previously suggested, or rather a clinical variation. PATIENTS AND METHODS We present a four-membered Greek fam...

Fetal hydantoin syndrome is a rare disorder that is believed to be caused by exposure of a fetus to the anticonvulsant drug phenytoin. The classic features of fetal hydantoin syndrome include craniofacial anomalies, prenatal and postnatal growth deficiencies, underdeveloped nails of the fingers and toes, and mental retardation. Less frequently observed anomalies include cleft lip and palate, mi...