BACKGROUND Hurthle cells of the thyroid gland are very rich in mitochondria and oxidative enzymes. As a high level oxidative metabolism may lead to higher level of oxidative stress and can be associated with an increased risk for cancer, we investigated whether common functional polymorphisms in antioxidant genes (SOD2, CAT, GPX, GSTP1, GSTM1 and GSTT1) are associated with the development or cl...

A 75-year-old male patient with non-avid radioiodine Hurthle cell carcinoma was evaluated by 99m Tc- octreotide scintigraphy, in order to find possible metastatic lesions. A bony metastatic lesion was detected by this procedure which was confirmed by histopathology.99mTc-octreotide scintigraphy is a precise and cost-effective imaging modality for detection of non-iodine av...

type of midline neck masses in children. Though usually benign, 1% of cysts may undergo neoplastic change. The most common histological subtype is papillary carcinoma (80%) followed in order of frequency by mixed follicular-papillary, squamous, follicular, anaplastic, and hurthle-cell carcinoma (1). The synchronous occurrence of thyroglossal duct carcinoma and thyroid carcinoma in the thyroid g...

Among thyroid neoplasms, Hurthle cell tumors (HCTs) have traditionally been a distinct diagnostic category. Hurthle cell adenomas are encapsulated follicular lesions with benign behavior. Hurthle cell carcinomas exhibit unequivocal capsular and/or vascular invasion; they are aggressive tumors with a poor prognosis. Recently, Hurthle cell papillary thyroid carcinomas (PTCs) have been identified ...

Hyperfunctioning nodules of the thyroid are thought to only rarely harbor thyroid cancer, and thus are infrequently biopsied. Here, we present the case of a patient with a hyperfunctioning thyroid nodule harboring thyroid carcinoma and, using MEDLINE literature searches, set out to determine the prevalence of and characteristics of malignant "hot" nodules as a group. Historical, biochemical and...

A 36-year-old man was found to have Hurthle cell carcinoma, as diagnosed with surgical pathology after a lobectomy of the thyroid. A post-operative magnetic resonance imaging scan revealed a small mass in the lower pole of the right thyroid and a computed tomography scan showed bilateral nodules in the lungs and the neck, and multi-focal disease in the liver. He was treated with a docetaxel and...