chromosome-centric human proteome project (c-hpp) is a recent initiative to rationalize and analyze gene-protein and protein-protein interactions in normal and disease conditions. this initiative is aimed to generate the proteomic atlas explaining the molecular architecture of the human body and was initiated in response to the hurdles identified during analyzing the human genome project (hgp)....

Human fibrinogen chromatographed on DEAE-cellulose resolves into two components containing 85% (peak 1 ) and 15% (peak 2) of the total fibrinogen. Peak 1 and peak 2 differ only in the composition of their ‘y chains, with peak 1 containing only one type of “y chain and peak 2 containing equal amounts of ‘y chain and a second chain, called ‘y’. In an effort to explain the difference in the amount...

Yersiniosis is a food-borne illness that has become more prevalent in recent years due to human transmission via the fecal-oral route and prevalence in farm animals. Yersiniosis is primarily caused by Yersinia enterocolitica and less frequently by Yersinia pseudotuberculosis. Infection is usually characterized by a self-limiting acute infection beginning in the intestine and spreading to the me...

This paper reviews past and present trends in mapping the human Y chromosome. So far, mapping has essentially used a combination of cytogenetic and molecular analyses of Y-chromosomal anomalies and sex reversal syndromes. This deletion mapping culminated recently in the isolation of the putative sex-determining locus TDF. With the availability of new separation and cloning techniques suited for...

The receptor for human interferon-y (IFN-y) was purified from foreskin fibroblasts. Triton X-100 extracts obtained from either intact cells or membrane preparations were passed through an immobilized interferon-? column. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of eluted fractions revealed a major band of M, = 95,000 and minor bands of M. = 80,000 and 60,000. Further...

introduction: over expression of selected peptide receptors in human tumors has been shown to represent clinically relevant targets for cancer diagnosis and therapy. the aim of this work was to investigate neuropeptide y (npy) as a new radiopharmaceutical for diagnosis of breast cancer. methods: a neuropeptide y analogues with y1 receptor preference and agonistic properties was synthesized by s...

All living organisms are exposed to ionizing radiation comprising cosmic rays coming from outer space, terrestrial nuclides occurring in the earth’s crust, building materials, air, water and foods and in the human body itself. The exposures are constant and uniform for all individuals everywhere including the dose from ingestion of 40K in food. Cosmic rays are, more intense at higher alt...

conclusions albumin gradient method is the enrichment of y-bearing chromosome sperms. separation of spermatozoa by albumin gradient method, introduced by ericsson, is a suitable method for sex selection of male offspring. this technique is safe, because it neither requires toxic materials during sperm separation, nor involves embryo manipulation. objectives the study aimed to assess the separat...