β2m: β2-Microglobulin; β2m-free HC: β2m-free Heavy Chain; CTL: CD8+ Cytotoxic T Lymphocytes; DSA: Donor Specific Antibodies; HC: Heavy Chain Polypeptide; HLA: Human Leukocyte Antigens; HLA-I: Human Leukocyte Antigen Class I; HLA-II: Human Leukocyte Antigen Class II; IFNγ: Interferon-γ; kDa: kilodalton; MHC: Major Histocompatibility Complex; MMP: Matrix Metalloproteinase; rHLA: Recombinant HLA; ...

BACKGROUND Bone marrow transplantation has been used in the treatment of various diseases, especially hematologic diseases. The success of this treatment, among other factors, requires human leukocyte antigens (HLA) compatibility between patient and donor. Knowing the human leukocyte antigens allele group and haplotype frequencies as well as the linkage disequilibrium between alleles of differe...

Twelve leukocyte antigens have been determined by the method of cytotoxicity in v~tro on leukoblasts from 38 patients with acute leukemia, using two batteries of isoimmune human sera. None of these antigens was absent in this leukemic population. The presence of the leukocyte antigens 1, 3, 4, 6, and 7 of the Hu-1 system (5) was confirmed by absorption experiments. In 17 patients, the leukocyte...