maternal leukemia inhibitory factor (lif) is required for successful implanta¬tion in mice, but little is known about its role and expression in human reproduc¬tion. here we report on the pattern of lif mrna expression in 30 samples of previously fertile and 11 infertile human endometrium, 10 samples of previously fertile post-menopausal endometrium and 10 uterine (fallopian) tubes from pre¬vio...

The human endometrium develops new capillaries from existing microvessels, i.e. angiogenesis, which then undergo maturation and remodeling, i.e. investment of microvessels with periendothelial mural cells, into a new vascular network during each menstrual cycle. Improper vascularization of the endometrium may cause implantation failure and infertility. Estrogen and progesterone have pivotal rol...

Evidence is gradually accumulating about acquired somatic chromosome anomalies, particularly those of neoplasms. Unfortunately, control observations are almost entirely lacking. It is generally assumed that all the tissues of the body consist of cells with the normal karyotype as it is seen in cultured lymphocytes or fibroblasts, but this has not yet been shown to be the case. Even bone-marrow,...

BACKGROUND Human endometrium is a highly regenerative tissue. We hypothesized that the source of endometrial stromal and vascular regeneration is a resident stromal stem/progenitor cell population. Putative human endometrial stromal stem/progenitor cells have been identified using clonal assays, a retrospective functional stem cell assay. Therefore, the aim of this study was to screen potential...

OBJECTIVE To study the dynamics of the expression and localization of the mu opioid receptor (MOR) in human endometrium throughout the menstrual cycle. DESIGN Analysis of human endometrial samples from different menstrual cycle phases (menstrual, early/midproliferative, late proliferative/early secretory, midsecretory, and late secretory) by reverse transcription-polymerase chain reaction, We...

Corticotrophin-releasing hormone (CRH) has been identified in several peripheral tissues, including the female reproductive organs. CRH is expressed in the placenta, myometrium, epithelial endometrium and the endometrial stromal cells at all phases of the menstrual cycle. Similarly, CRH receptors are present in pregnant and non-pregnant myometrium, placenta and endometrium. Putative roles of CR...