Auxin a plant growth hormone, has a metabolic pathway that includes molecules and enzymes like those in animal brains. In this study, tomato plant seedlings (Lycopersicon esculenta) were used to investigate the fate of fluorine-tagged 5-hydroxytryptophan (PF-5-HTP) being developed for fluorine spectroscopy and imaging. Seedlings were treated with high or low concentrations of 5-HTP or PF-5-HTP ...

HTP is an SMT Modulo theorem prover similar to many others.[2–6, 9, 11] As input, HTP accepts problems using the SMT-LIB format[8]. As output, HTP will answer either SAT, UNSAT or UNKNOWN. Alternatively, HTP can be run in a preprocessing mode in which the output is the simplified problem in SMTLIB format. An evidence file showing the derivation in a human readable form can be produced. There is...

Hilbert’s Tenth Problem over the rationals is one of the biggest open problems in the area of undecidability in number theory. In this paper we construct new, computably presentable subrings R ⊆ Q having the property that Hilbert’s Tenth Problem for R, denoted HTP(R), is Turing equivalent to HTP(Q). We are able to put several additional constraints on the rings R that we construct. Given any co...

Alcalase hydrolysis of liquid egg white was used to produce 5-hydroxytryptophan (HTP) under various conditions and investigate the sleep-potentiating activity of liquid egg white hydrolysate (LEH) on pentobarbital-induced sleep. Alcalase hydrolysis yielded the highest content of 5-HTP (13.50 μg/mL), while neutrase hydrolysis showed the lowest 5-HTP content (5.23 μg/mL). The liquid egg white to ...

5-hydroxytryptophan (5-HTP) is a direct 5-hydroxytryptamine (5-HT) precursor used to assess central serotonergic function. Its use has been limited by a narrow window between neuroendocrine changes and side effects, and variable kinetics related to inconsistent administration modes. By combining 5-HTP with carbidopa (CBD), increased bioavailability for brain penetration and decreased peripheral...

BACKGROUND Accurate and efficient detection of sub-microscopic malaria infections is crucial for enabling rapid treatment and interruption of transmission. Commercially available malaria LAMP kits have excellent diagnostic performance, though throughput is limited by the need to prepare samples individually. Here, we evaluate the clinical performance of a newly developed high throughput (HTP) s...

Serotonin (5-hydroxytryptamine [5-HT]) has been implicated in a variety of physiological and pathological functions. Multiple steps of enzyme reactions enable biosynthesis of 5-HT. The first and rate-limiting step of the reaction is the synthesis of 5-hydroxy-L-tryptophan (5-HTP) from L-tryptophan. This step is dictated by an enzyme, tryptophan hydroxylase (TPH). TPH requires 6R-L-erythro-5,6,7...

Background One of the objectives of the health transformation plan (HTP) in Iran is to reduce out-of-pocket (OOP) payments for inpatient services and eradicate informal payments. The HTP has three phases: the first phase (launched in May 5, 2014) is focused on reducing OOP payments for inpatient services; the second phase (launched in May 22, 2014) is focused on primary healthcare (PHC) and the...

For a ring R, Hilbert’s Tenth Problem HTP(R) is the set of polynomial equations over R, in several variables, with solutions in R. When R = Z, it is known that the jump Z′ is Turing-reducible to HTP(Z). We consider computability of HTP(R) for subrings R of the rationals. Applying measure theory to these subrings, which naturally form a measure space, relates their sets HTP(R) to the set HTP(Q),...

Positron emission tomography (PET) with 11C-labeled 5-hydroxytryptophane (5-HTP) is a sensitive technique to visualize neuroendocrine tumours (NETs), due to high intracellular uptake of amine-precursors like L-dihydroxyphenylalanine (L-DOPA) and 5-HTP. NETs are often small and difficult to localize in spite of overt clinical symptoms due to hormonal excess. In our study, 38 consecutive NET pati...