Introduction of a number of HIV-1 protease (PR) inhibitors as anti-AIDS drugs has drastically changed the clinical prognosis for the outcome of this disease, from almost invariably lethal to chronic. This achievement also represented the first major success of structure-based drug design, encouraging the use of similar approaches to other major diseases, such as cancer. We have now identified a...

Abstract Background Human T-lymphotropic virus 1 (HTLV-1) is etiologically associated with the chronic inflammatory neurodegenerative disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) Annexin A1 (AnxA1) an anti-inflammatory protein proposed neuroprotective and anti-neuroinflammatory functions. We hypothesized that ANXA1 gene expression may be dysregulated in HTLV-1-inf...

Bovine leukemia virus (BLV) is a valuable model system for understanding human T-lymphotropic virus 1 (HTLV-1); the availability of an infectious BLV clone, together with animal-model systems, will help to explore anti-HTLV-1 strategies. Nevertheless, the specificity and inhibitor sensitivity of the BLV protease (PR) have not been characterized in detail. To facilitate such studies, a molecular...

Abstract Background Frequent and rapid development of myelopathy has been reported in individuals with human T-lymphotropic virus type 1 (HTLV-1) infection following solid organ transplantation. There is no information regarding HTLV-2, a closely related that often infects injection drug users. Methods This study includes retrospective analysis all consecutive transplants performed during the l...


 Introducción: La paraparesia espástica es una infección causada por el virus linfotrópico de células T humanas (HTLV-1). Se caracteriza mielopatía lenta instauración que compromete principalmente los miembros inferiores. Afecta más a mujeres varones y las principales vías transmisión son: sanguínea, sexual vertical (principalmente durante la lactancia).
 Presentación del caso: Gesta...

The lifelong infection with the human T lymphotropic virus type 1 (HTLV-1) has been associated a variety of clinical manifestations; one less-explored is HTLV-1-associated pulmonary disease. Imaging lung damage caused by HTLV-1 hyperinflammatory cascade can be similar to sequelae from TB infection. Our study aims describe lesions HTLV-1-positive patients without past or current active and evalu...

Human immunodeficiency virus type 1 (HIV-1) and human T-lymphotropic I (HTLV-I) are two retroviruses that have a similar fashion of transmission via sharp objects contaminated by viruses, transplant surgery, transfusion, sexual relations. Simultaneous infections with HTLV-I HIV-1 usually occur in areas where both viruses become endemic. CD4+T cells the main targets HTLV-I, while can infect macr...

Retroviruses HIV-1 and HTLV-1 are chiefly considered to be the most dangerous pathogens in Homo sapiens. These two viruses have structurally unique protease (PR) enzymes, which are having common function of its replication mechanism. Though HIV PR drugs failed to inhibit HTLV-1 infections, they emphatically emphasise the need for designing new lead compounds against HTLV-1 PR. Therefore, we tri...

Abstract Backgrounds Therefore, reports on the risk of HTLV-1-related diseases in organ transplantation have increased recent years, and management HTLV renal remains a challenge. Patients methods We retrospectively analyzed four HTLV-1-positive recipients or donors among 89 cases from 2006 to 2021. Results Among recipients, two patients developed adult T cell leukemia/lymphoma (ATL) derived at...