نتایج جستجو برای: hsa denaturation
تعداد نتایج: 10128 فیلتر نتایج به سال:
BACKGROUND 6-Shogaol, one of the main bioactive constituents of Zingiber officinale has been shown to possess various therapeutic properties. Interaction of a therapeutic compound with plasma proteins greatly affects its pharmacokinetic and pharmacodynamic properties. PURPOSE The present investigation was undertaken to characterize the interaction between 6-shogaol and the main in vivo transp...
The effect of confinement and energy transfer on the dynamics of a molecular magnet, known as a model system to study quantum coherence, is investigated. For this purpose the well-known polyoxovanadate [V(15)As(6)O(42)(H(2)O)](6-) (V(15)) is incorporated into a protein (human serum albumin, HSA) cavity. Due to a huge overlap of the optical absorption spectrum of V(15) with the emission spectrum...
1. The percentage binding of testosterone (T) and oestradiol (E2) to sex hormone binding globulin (SHBG) and human serum albumin (HSA) was determined over a range of SHBG concentrations of 16-250 nmol of dihydrotestosterone (DHT) bound/l. It was found that the binding of both T and E2 to HSA was a function of their binding to SHBG and bore an inverse relationship to it. After removal of both SH...
We describe the development of a novel serum albumin binding protein showing an extremely high affinity (K(D)) for HSA in the femtomolar range. Using a naturally occurring 46-residue three-helix bundle albumin binding domain (ABD) of nanomolar affinity for HSA as template, 15 residues were targeted for a combinatorial protein engineering strategy to identify variants showing improved HSA affini...
Human serum albumin has been used as a model protein for protein folding and ligand binding studies over many decades. Due to its long life period and high concentration in plasma, HSA is highly sensitive to glycation. It is reported that 175 mg/dL glucose concentration is a threshold of kidney activity for the beginning of excretion of glucose. pH denaturation of HSA in absence and presence of...
The remarkable ability of guanidinium chloride (GdmCl) to denature proteins is a well studied yet controversial phenomenon; the exact molecular mechanism is still debatable, especially the role of hydration dynamics, which has been paid less attention. In the present contribution, we have addressed the issue of whether the collective hydrogen bond dynamics of water gets perturbed in the presenc...
Human serum albumin(HAS) is important for the body, as it performs a set of functions such maintaining osmotic pressure inside cells, transporting drugs and ions, others. The fraudulent process preparations may lead to deterioration patient's health condition sometimes death. In current study, two types albumin that were not authorized by Yemeni ministry entered country through smuggling studie...
Introduction Polychlorinated biphenyls (PCBs), organic lipophilic pollutants that accumulate through diet and increase with age, have been associated polycystic ovary syndrome (PCOS) shown to affect microRNA (miRNA) expression. This work aimed determine if PCBs were circulating miRNAs whether there any correlations serum PCB/miRNA levels hormonal changes. Methods 29 non-obese PCOS healthy contr...
Abstract Objectives Coronavirus disease 2019 (COVID-19) is a kind of viral pneumonia which caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MicroRNAs (miRNA) are small non-coding RNAs consisting 19–25 nucleotides and play role in post-transcriptional gene regulation. We have focused on serum expression levels microRNA novel concept host–virus interactions. MicroRNA profil...
Introduction In gynecologic oncology, ovarian cancer is a great clinical challenge. Because of the lack typical symptoms and effective biomarkers for noninvasive screening, most patients develop advanced-stage by time diagnosis. MicroRNAs (miRNAs) are type non-coding RNA molecule that has been linked to human cancers. Specifying diagnostic determine non-cancer samples difficult. Methods By usin...
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