BACKGROUND This study aimed to identify hotspots in research on clinical competence measurements from 2012 to 2016. METHODS The authors retrieved literature published between 2012 and 2016 from PubMed using selected medical subject headings (MeSH) terms. They used BibExcel software to generate high-frequency MeSH terms and identified hotspots by co-word analysis and cluster analysis. RESULT...

Meiotic recombination is initiated by DNA double-strand breaks (DSBs) made by Spo11 (Rec12 in fission yeast), which becomes covalently linked to the DSB ends. Like recombination events, DSBs occur at hotspots in the genome, but the genetic factors responsible for most hotspots have remained elusive. Here we describe in fission yeast the genome-wide distribution of meiosis-specific Rec12-DNA lin...

Criminal activities are unevenly distributed over space. The concept of hotspots is widely used to analyze the spatial characters of crimes. But existing methods usually identify hotspots based on an arbitrary user-defined threshold with respect to the number of a target crime without considering underlying controlling factors. In this study we introduce a new data mining model – Hotspots Optim...

Background Malaria control strategies need to respond to geographical hotspots of transmission. Detection of hotspots depends on the sensitivity of the diagnostic tool used. Methods We conducted cross-sectional surveys in 3 sites within Kilifi County, Kenya, that had variable transmission intensities. Rapid diagnostic test (RDT), microscopy, and polymerase chain reaction (PCR) were used to de...

We describe a whole-genome comparative analysis of the human, mouse, and rat genomes to describe the average substitution patterns of four genomic regions: ancient repeats, rodent-specific DNA, exons, and conserved (coding and noncoding) regions, and to identify rodent evolutionary hotspots. In all types of regions, except the rodent-specific DNA, the rat branch is slightly longer than the mous...

Crime tends to cluster geographically. This has led to the wide usage of hotspot analysis to identify and visualize crime. Accurately identified crime hotspots can greatly benefit the public by creating accurate threat visualizations, more efficiently allocating police resources, and predicting crime. Yet existing mapping methods usually identify hotspots without considering the underlying corr...

Human immunodeficiency virus (HIV) infection and the acquired immune deficiency syndrome (AIDS) exhibit variable patterns among the provinces of China. Knowledge of the geographical distribution of the HIV/AIDS epidemic is needed for the prevention and control of AIDS. Thus, the cumulative number of reported cases of HIV/AIDS from the period 1985-2013, and the incidence rate of AIDS in 2013 wer...

A major challenge in Spoken Dialogue Systems (SDS) is the detection of problematic communication (hotspots), as well as the classification of these hotspots into different types (root cause analysis). In this work, we focus on two classes of root cause, namely, erroneous speech recognition vs. other (e.g., dialogue strategy). Specifically, we propose an automatic algorithm for detecting hotspot...

Several recent large clinical trials evaluated HIV vaccine candidates that were based on recombinant adenovirus serotype 5 (rAd-5) vectors expressing HIV-derived antigens. These vaccines primarily elicited T-cell responses, which are known to be critical for controlling HIV infection. In the current study, we present a meta-analysis of epitope mapping data from 177 participants in three clinica...