objective: metabolic side effects of the second generation (atypical) antipsychotics have been a forefront of attention since their availability. one common   concern   is   the   development   of   hyperglycemia   and   insulin resistance. the aim of this study was to evaluate the effect of early initiation of omega-3 fatty acids supplementation on glucose-insulin homeostasis in a group of psy...

background: leptin is an adipokine that circulates in a free form and bound to a soluble leptin receptor. patients with polycystic ovary syndrome have increased insulin resistance and high incidence of obesity. objective: this study was carried out to evaluate levels of leptin and free leptin in women with polycystic ovarian syndrome (pcos) and note any relationships with insulin resistance and...

background: polycystic ovarian syndrome (pcos) is a common disease among women in fertility ages and cause severe insulin resistance. hyperhomocysteinaemia is said to be among the features of pcos that could influence its outcome. objective: this study aimed to investigate whether hyperhomocysteinaemia exists in pcos and if it is related to insulin resistance in the affected patients. materials...

conclusions based on these data, we can argue that circulating glucose concentration is not directly affected by serum resistin in t2dm. it seems that resistin affects glucose indirectly, through insulin resistance. results we found that serum resistin had a positive significant correlation with insulin resistance (p = 0.000, r = 0.64). no significant correlation was found between serum resisti...

background: polycystic ovary syndrome (pcos) is the most common endocrine disorder in females of reproductive age. insulin resistance is a frequent metabolic disturbance in pcos. vitamin d deficiency is a common problem. accumulating evidence suggests that vitamin d has a role on insulin sensitivity so may contribute to reduction of hyperandrogenemia. objective: the aim was to determine the eff...

background leptin, a protein released from adipose tissue, could have significant role in pathogenesis of obesity and type 2 diabetes mellitus. conclusions it is speculated that lower serum leptin levels in diabetic patients may be a consequence of male gender. moreover, results suggest that serum leptin level in women is influenced differently than that in men. results the serum leptin level i...

background: the aim of this study was to assess the association between insulin resistance, metabolic syndrome and nonalcoholic fatty liver disease (nafld) in chinese adults. methods: fifty five subjects with nafld and 55 controls were enrolled for the study. waist circumference, blood pressure, plasma triglyceride, high density lipoprotein cholesterol and fasting plasma glucose concentrations ...

INTRODUCTION Insulin resistance is the pathophysiological key to explain metabolic syndrome. Although clearly useful, the Homeostasis Model Assessment index (an insulin resistance measurement) has not been systematically applied in clinical practice. One of the main reasons is the discrepancy in cut-off values reported in different populations. We sought to evaluate in a Portuguese population t...