The purpose of this study is to compare the clinicopathological characteristics and outcomes of esophageal foreign body (FB) ingestion in adults between weekdays and holidays. This is a retrospective study including 1058 patients with esophageal FB ingestion from 2012 to 2016. Patient characteristics, the types and locations of FB, and clinical outcomes were compared between patients on weekday...

BACKGROUND Recent research on the patterns of self-harm around public holidays is lacking. This study used national data to examine the patterns of hospital-treated self-harm during public holidays, and to examine associated factors. METHODS Data on self-harm presentations to all emergency departments were obtained from the National Self-Harm Registry Ireland. The association between self-har...

Introduction: Tamoxifen is one of the most common treatment opportunities for hormonal positive breast cancer. Despite its good tolerability, patients demonstrate decreasing adherence over years impacting on therapeutic success. PBPK modeling was applied to demonstrate the impact of drug holidays on plasma levels of tamoxifen and its active metabolite endoxifen for different CYP2D6 genotypes. M...

OBJECTIVE To compare the mortality of patients in a palliative care unit on working days with that on weekends and public holidays. DESIGN Retrospective database study. SETTING Palliative care unit in Germany. POPULATION All admissions to palliative care unit between 1 January 1997 and 31 December 2008. MAIN OUTCOME MEASURE The impact of day type (working days or weekends and public hol...

If you are reading this editorial in the week of publication, chances are that you do not work in one of the countries bordering the Mediterranean. If you are in Scandinavia, this is probably your first opportunity even to read my editorial from July. Most of Europe now takes a full four or five weeks of vacation, usually corresponding to the calendar month of July in the north or August in the...

Background Data regarding the influence of weekends and Chinese national holiday's admission on the outcomes of patients with ST-elevated myocardial infarction (STEMI) is lacking. This study sought to investigate the effect of Chinese national holidays and weekend admission on outcomes in patients with STEMI undergoing primary percutaneous coronary intervention (PPCI). Methods Patients presen...

Despite the reduction of mortality rate in the past years, coronary artery diseases (CADs) are the main reason of death in the world. Many factors including changes in nurses and medical staffs, numbers of beds influence the mortality rate of patients admitted in holidays and night time. The objectives of this study were to clarify the association between mortality rate and off-hours and holida...