Introduction: Prostate cancer is a multifaceted disease comprises distinct biological subtypes with varied spectrum of clinical, pathologic and molecular features with different prognostic and therapeutic implications. Over the last few decades there have been outstanding advances in prostate cancer management leading to earlier detection of disease. Prostatic cancer diagnosis is based on a com...

BACKGROUND Fibromatosis-like metaplastic carcinoma is a newly described metaplastic breast tumor, literature on which is still evolving. CASE PRESENTATION A 77-year-old lady presented with a 2 x 2 cm mass with irregular margins in the upper and outer quadrant of left breast. Fine needle aspiration cytology (FNAC) from the lump was inconclusive. A lumpectomy was performed and sent for frozen s...

• The use of immunohistochemistry for basal cell markers and AMACR for the diagnosis of limited adenocarcinoma of the prostate should be used as an adjunct to the H&E diagnosis as there is false positive and negative staining with these markers. • Examples of labeling of prostate adenocarcinoma with basal cell markers include: aberrant scattered HMWCK staining of cancer cells; rarely the retent...

The diagnosis of prostate cancer is challenging because of the existence of lesions that mimic adenocarcinoma. Such a lesion is atypical adenomatous hyperplasia (AAH) or adenosis, which represents a proliferation of crowded, small to medium glands with basal cell layer invariably present, but often inconspicuous on routine stains. The importance of the lesion lies in the potential for being mis...

Introduction: Alpha-methylacyl-CoA-racemase (AMACR) is a tumor marker expressed in prostate cancer. Literature data concerning its expression in different variants and unusual patterns of prostate carcinoma are uneven and less numerous. The present study investigates the AMACR expression in some rare forms of prostate carcinoma. Material and methods: Distinct variants and unusual patterns of pr...

Introduction and importance: Collision tumors refer to the phenomenon where two or more different unrelated occur in same location of an organ form a single lesion. We present first case renal collision composed clear cell carcinoma (ccRCC) collecting duct (CDC) treated with combined therapy nivolumab ipilimumab. Case presentation: An 89-year-old male presented...

The current study aimed to determine the incidence of various benign mimickers of prostatic adenocarcinoma most commonly encountered in a busy consultation practice. All prostate needle biopsies from the consult service of one of the authors were prospectively evaluated over a 7-month period. Only cases with foci where the contributor questioned malignancy and which upon expert review the entir...

Background: Fibromatosis-like metaplastic carcinoma is a newly described metaplastic breast tumor, literature on which is still evolving. Case presentation: A 77-year-old lady presented with a 2 × 2 cm mass with irregular margins in the upper and outer quadrant of left breast. Fine needle aspiration cytology (FNAC) from the lump was inconclusive. A lumpectomy was performed and sent for frozen s...