In this paper, we introduce a discrete-time higher-order Markov-switching (HMS) model for measuring the risk of a portfolio. We suppose that the logarithmic returns from a risky portfolio is governed by a HMS model with the drift and the volatility switch over time according to the states of a discrete-time higher-order hidden Markov model (HHMM). We interpret the states of the HHMM as unobserv...

The last few years have witnessed an enormous study in the area of integrated hydrological modeling with GIS application. In this research, attempt was made to critically look at the application of HEC-GeoHMS which is an extension of ArcView in HEC-HMS; an HEC package which is a new generation of software being developed for rainfall-runoff simulation. The main role of HEC-GeoHMS is to formulat...

Myoepithelial cells, which surround ducts and acini of glandular organs, form a natural border separating proliferating epithelial cells from basement membrane and underlying stroma. Myoepithelial cells in situ and in vitro constitutively express high amounts of proteinase inhibitors that include tissue inhibitor of metalloproteinase 1, protease nexin-II, alpha-1 antitrypsin, and maspin. Human ...

A radiometric micro-volume procedure for measurement of erythrocytic hexose monophosphate shunt (HMS) activity in intact cells in vitro is described. The procedure is rapid, allowing 200 individual HMS determinations in a single experiment of 5 hr duration. The procedure is reproducible, yielding HMS activity means insignificantly different (P greater than 0.05) between replicate experiments. A...

A methodology is presented for extracting topographic, topologic, and hydrologic information, from the digital spatial data of a hydrologic system, for hydrologic modeling with HMS. Methods for stream and watershed delineation from digital elevation models are presented. After vectorizing the raster-based stream segments and watersheds, navigation fields are added to their tables to support top...

Histone modifications (HMs) are an important post-translational feature. Different types of HMs are believed to co-exist and co-regulate biological processes such as gene expression, and therefore are intrinsically dependent on each other. We develop inference for this complex biological network of HMs based on a graphical model using ChIP-Seq data. A critical computational hurdle in the infere...

While prior research reported altered fuel utilization stemming from pre-exercise modified starch ingestion, the practical value of this starch for endurance athletes who consume carbohydrates both before and during exercise is yet to be examined. The purpose of this study was to determine the effects of ingesting a hydrothermally-modified starch supplement (HMS) before and during cycling on pe...

abstract one of the techniques that has been used in different areas of sciences, and probably would be able to simulate complicated process of rainfall-run off is artificial neural network (ann). the purpose of this research is to evaluate the applicability of ann in rainfall- run off simulation and the comparison of the results to those produced by hec-hms model in azam river basin of herat i...

Heavy metals (HMs) immobilization in sewage sludge was investigated by using subcritical water technology (SCWT) in this study. The characteristics of sludge and toxicity of HMs were analyzed after SCWT process. The results showed that besides large reduction in sludge volume, SCWT had some positive effect on HMs dissolution into liquid phase, while the majority of HMs was still accumulated in ...

Developments in Holonic Manufacturing Systems (HMS) have been reported in three main areas: architectures, algorithms, and methodologies for HMS. Despite the advancements obtained in the first two areas the methodologies for HMS have not received great attention. To date, many of the developments in HMS have been conducted in an almost “empirical way”, without design methodology. There is a def...