background: hla b27 is a sub class of human leukocyte antigen (hla) class i molecule. it was known as the first genetic risk factor associating with ankylosing spondylitis (as). allele frequency of hla-b27 alleles is different across populations. the present study is aimed to investigate the prevalence of hla-b27 in patients referred to danesh clinical laboratory during 2014 to 2015. methods an...

A civil paternity investigation involving the parents of deceased alleged father in order to establish a family relationship is presented. On basis 23 autosomal short tandem repeat (aSTR) genotyping results, conclusive proof was not achieved, as probability (W) calculated 0.99988. Additional genetic data 17 classical and non-classical human leukocyte alleles (HLA) typing by next-generation sequ...

aim : the aim of this study was to evaluate the likelihood ratio and frequency of dq2 and dq8 in iranian patients with celiac disease (cd). background : the hla dq2 and hla dq8 are the important mediators in the development of celiac disease. a few studies evaluated the frequency of hla dq2 and hla dq8 haplotypes among the iranian population with low sample size. patients and methods : in this ...

the most important factor in donor-recipient matching for hematopoietic stem cell transplantation is their hla typing. for many patients, we can not find a full-matched donor. in high risk patients, one locus  mismatched related donors are suitable alternatives. (1, 2) since the matching of patients and their siblings usually is based on low resolution hla typing, the matching of one locus mism...

introduction: considering the role of hla matching in transplant outcome, the quality of hla-dr typing is clearly an important issue.in recent years serologic methods have been replaced with dna based typing methods.the main objective of this study was to compare hla-dr typing data obtained from existing serologic method with that obtained by the new pcr-ssp method. material and methods: fifty-...