Abstract Sepsis is a life-threatening condition caused by the extreme release of inflammatory mediators into blood in response to infection (e.g., bacterial infection, COVID-19), resulting dysfunction multiple organs. Currently, there no direct treatment for sepsis. Here we report an abiotic hydrogel nanoparticle (HNP) as potential therapeutic agent late-stage The HNP captures and neutralizes a...

Objective Imbalance between production of reactive oxygen species (ROS) and total antioxidant capacity in testis, epididymis, and seminal fluid can eventually lead to subfertility and infertility. Abnormal chromatin packaging, and DNA fragmentation is considered as the main underlying causes. In this regard, we aimed to assess relationship between sperm parameters with DNA damage, protamine def...

The phosphate content of rat thymus histones was determined. As expected for a replicating tissue, histones 1 and 2B were more phosphorylated and had higher 32P uptakes than did histones from resting liver nuclei; the other histones all showed 32P uptake, but the phosphate content and uptake of histone 2A was about half that for liver histone 2A. When thymus nuclei were incubated in a slightly ...

Histones belong to a family of highly conserved proteins in eukaryotes. They pack DNA into nucleosomes as functional units chromatin. Post-translational modifications (PTMs) histones, which are dynamic and can be added or removed by enzymes, play critical roles regulating gene expression. In plants, epigenetic factors, including histone PTMs, related their adaptive responses the environment. Un...

1. The preparation and properties of lysine-rich histones, which differ in a number of respects from the classical arginine-rich histones, have been described. 2. Lysine-rich histones, like those previously known, are located in cell nuclei. 3. Lysine-rich histones dissociate more readily from combination with nucleic acid than do other histones.