conclusions cyclosom and histamine synergistically exert catalepsy in old rats. in light of these data, the combination of the decreased brain level of somatostatin and increased brain level of histamine may be of pathogenic relevance for extrapyramidal signs in pd. results cyclosom (0.2, 1.0, and 5.0 µg) and histamine (1.0 and 10.0 µg) alone were ineffective in both young and old animals. in c...

Few drugs have so rapidly gained an established place in modern medicine as the histamine H, receptor antagonists. As a result of the inventiveness of James Black and his colleagues, the theoretical concept of a second class of histamine receptors became a therapeutic reality. The failure of classic antihistamine drugs (more appropriately H1 receptor antagonists) to block the actions of histami...

  Objective(s): The present study investigated the effects of microinjection of histamine and histamine H1, H2, and H3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (PSC) on inflammatory pain.   Material and Methods: Two stainless steel guide canulas were bilaterally implanted into the PSC of anaesthetized rats. Inf...

BACKGROUND Dyspeptic symptoms are commonly reported complaints in clinical practice and are mostly the result of functional disorders. Empirical treatment with histamine H2-receptor blockers or gastroprokinetics for 2-4 weeks has frequently been proposed as first line management of these patients. The clinical trials which support the use of these agents, show a high variation in clinical succe...

We evaluated changes in the binding properties of sedative and non-sedative histamine H1-receptor antagonists induced by internalization of H1 receptors in intact human U373 MG astrocytoma cells. Internalization of H1 receptors was induced without their degradation by treatment with 0.1 mM histamine for 30 min at 37 degrees C, and then the intact cell binding assay was performed at 4 degrees C....

Study was made of the developmental mechanism of histamine induced ulcers and inhibitory effects of receptor antagonists from the view point of gastric acidity and microvasculature of the gastric mucosa, and the following results were obtained. 1. In histamine induced ulcers, hypersecretion of gastric acid caused by histamine is not the primary developmental mechanism of the lesion. The main ca...

It has long been established that histamine plays a role as a mediator of inflammation. From numerous studies, it has been well known that the amine has many pharmacological actions on a variety of organs. To evaluate the role of histamine in pain perception, we generated HDC knockout mice using a gene targeting method. Histamine is a hydrophilic autacoid, and in most tissues it is stored and s...

3H-Cimetidine binding to plasma membranes of isolated guinea pig gastric glands was investigated, and the effects of five H2-receptor antagonists on 3H-cimetidine binding and histamine stimulation of cellular cAMP were compared. Of the five cations tested, Cu++ markedly increased specific 3H-cimetidine binding. 3H-Cimetidine had high affinity (Kd = 0.41 x 10(-6) M) and low affinity (Kd = 12.8 x...