objective(s): the present study investigated the effects of microinjection of histamine and histamine h1, h2, and h3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (psc) on inflammatory pain.   material and methods: two stainless steel guide canulas were bilaterally implanted into the psc of anaesthetized rats. inflammator...

histamine h3 receptor subtype has been the target of several recent drug development programs. quantitative structure-activity relationship (qsar) methods are used to predict the pharmaceutically relevant properties of drug candidates whenever it is applicable. the aim of this study was to compare the predictive powers of three different qsar techniques, namely, multiple linear regression (mlr)...

the role of endogenous histamine and h1, h2 and h3 central receptors on food intake in broiler chickenswas investigated. for this purpose, a probe was used to manipulate the concentration of endogenoushistamine by intracerebroventricular (icv) injection of thioperamide, an h3 receptor antagonist, and r-α-methylhistamine, an h3 receptor agonist and subsequently the effects of brain histaminergic...

objective: crocin and safranal, as the major constituents of saffron, have many biological activities. this study investigated the effects of crocin and safranal on yawning response induced by intracerebroventricular (i.c.v.) injection of histamine in rats. materials and methods: in ketamine/xylazine-anesthetized rats, a guide cannula was implanted in the right ventricle of the brain and yawnin...

teucrium polium is used for treatment of visceral pain in iranian folkloric medicine. in this studyantinociceptive mechanisms of t. polium hydroethanolic extract were examined by acetic acid-inducedwrithing test as a model of visceral pain in male nmri mice. to reveal the antinociceptive mechanisms ofthe extract, we examined the effects of opioidergic, serotonergic, adrenergic and histaminergic...

the role of histamine in the regulation of food and water intake in mammals and birds of the review, this study evaluated the effects of intraperitoneal administration of chlorpheniramine as histamine h1-receptor antagonist, in broiler chicks on feed intake and satiety in water and was hungry. 32 male ross broiler chicks reared in groups of four weeks, 16 samples (control and test) were then in...

the role of histamine in the regulation of food and water intake in mammals and birds of the review, this study evaluated the effects of intraperitoneal administration of famotidine as histamine h2 -receptor antagonist, in broiler chicks on feed intake and satiety in water and was hungry. 32 male ross broiler chicks reared in groups of four weeks, 16 samples (control and test ) were then inject...

introduction: considering the long traditional history of anti-inflammatory and anti-spasmodic effects of matricria spices on the gastrointestinal system, the present study aimed to investigate the role of calcium channels and histamine receptors in the inhibitory effects of hydroalcoholic dry extract of german chamomile (matricaria recutita l.) on the isolated rabbit jejunum. methods: all expe...

The role of endogenous histamine and H1, H2 and H3 central receptors on food intake in broiler chickenswas investigated. For this purpose, a probe was used to manipulate the concentration of endogenoushistamine by intracerebroventricular (ICV) injection of thioperamide, an H3 receptor antagonist, and R-α-methylhistamine, an H3 receptor agonist and subsequently the effects of brain histaminergic...