colchicine, a potent neurotoxin derived from plants, has been recently introduced as a degenerative toxin of small pyramidal cells in the cortical area 1 of the hippocampus (ca1). in this study, the effect of the alkaloid in ca1 on the behaviors in the conditioning task was measured. injections of colchicine (1,5 μg/rat, intra-ca1) was performed in the male wistar rats, while the animals were s...

Background: Cerebral ischemia/ reperfusion leads to programmed cell death or planned apoptosis. Hippocampus is a very sensitive tissue cerebral ischemia. Propofol an anesthesia that recently the use of this drug as neuroprotective has been considered. In study, effect propofol on CA2 and CA3 areas hippocampus following ischemia was investigated.

abstractintroduction: previous investigations have shown that protein malnutrition can alters the structure and function of some areas of hippocampal formation. we investigated the effect of protein malnutrition on amygdaloid projections to the ca1 hippocampal area. in this study we investigated level and pattern of distribution of efferent projections from amygdala to hippocampus in the rat by...

conclusions these results suggest a negative correlation between mdma administration and adult hippocampal neurogenesis. results our results showed that mdma administration caused a decrease in neun expression in the experimental group compared with the control group. objectives due to the effect of neurogenesis on memory and learning, in this study, we investigated the effects of mdma on neun ...

background ecstasy or 3-4, methylenedioxymethamphetamine (mdma), as an amphetamine derivate, could lead to learning and memory impairment. objectives as the hippocampus is responsible for learning and memory, herein we evaluated acute and chronic effects of mdma on the structure of the hippocampus. materials and methods male wistar rats (200-250 g) received single or multiple injections of mdma...

background: tamoxifen treatment induced cell death in the hippocampus formation of the prenatal and postnatal rat. the present study delineates the effect of tamoxifen on developing hippocampus in prenatal, postnatal and full term neonate rats received certain doses of the partial antagonist tamoxifen. methods: after perfusion and fixation, the brains were removed and processed for light and el...

background: alzheimer’s disease (ad) is a neurodegenerative disorder with progressive loss of cognitive abilities and memory loss. the aim of this study was to compare neuropathological changes in hippocampus and brain cortex in a rat model of ad. methods: adult male albino wistar rats (weighing 250-300 g) were used for behavioral and histopathological studies. the rats were randomly assigned t...

Background: Sex steroids and their receptors exist in hippocampus and affect spatial learning and memory. This study was designed to measure testosterone level of CA1 and to assess the effect of spatial learning on its amount in left and right hippocampus of adult male rats. Methods: Sixteen rats were divided into two intact and castrated groups, and then trained in Morris water maze (MWM). An...

background and aims: this study examined sub-chronic effects of methamphetamine (meth) on the stereological parameters in the cornu ammonis (ca) of the hippocampus in adult mice. materials and methods: fifteen adult male mice, eight weeks old, were randomly divided into three groups: receive saline (controls), or low-dose (ld) 2.5 mg/kg meth, or high-dose (hd) 25 mg/kg meth, via daily intraperi...