An essential step during the intracellular life cycle of many positive-strand RNA viruses is the rearrangement of host cell membranes to generate membrane-bound replication platforms. For example, Nidovirales and Flaviviridae subvert the membrane of the endoplasmic reticulum (ER) for their replication. However, the absence of conventional ER and secretory pathway markers in virus-induced ER-der...

www.impactjournals.com/oncotarget 167 Oncotarget 2010; 1: 167-167 Src and Abl are non-receptor tyrosine kinases that promote tumor cell migration. This hallmark of malignant cell growth is required for tumor cell invasion and metastasis. However, mechanisms by which Src and Abl augment these events are not well defined. In this report [1], Khusial et al. have elegantly shown that Src activates ...