background: cervical cancer is one of the most important and commonly diagnosed types of cancer in females. there are different causes of cervical cancer, amongst which recurrent and persistent infection with hpv types 16 and 18 are the most renowned ones. these genotypes are the main factors in 99 % of cases in developed countries and 70 % in developing ones. due to the importance of these vir...

a b s t r a c t “addiction” is a multifaceted complicated disorder with many interrelated causes, as well as environmental and genetic features. several hereditary variables that have an effect on these features might work in together to influence vulnerability and the extent of being an addict. molecular re-sequencing of the latest and formerly researched genes holds a crucial place with regar...

OBJECTIVE This study evaluated the effect of the specific human papillomavirus (HPV) genotypes on severity and prognosis in cervical intraepithelial neoplasia (CIN) patients. METHODS The medical records of 446 patients treated with loop electrosurgical excision procedure (LEEP) were reviewed. The severity of CIN was categorized as CIN1/CIN2 versus CIN3+ including CIN3 and carcinoma in situ (C...

prematurity is the most common cause of neonatal death. risk factors of premature birth can be related with ethnicity and genetic. there is no comprehensive high sample size study in kurdish ethnicity to determine risk factors related to prematurity. this study evaluated risk factors of preterm labor in kurdish ethnicity.this case-control study was conducted in 200 preterm infants (case group) ...

background & aim: aids is one of the major public health challenges all over the world. perceived risk is a significant predictor of high-risk behaviors related to aids. women constitute more than half of the hiv patients, and the rate of female sex workers with aids is more than the rest of female population. therefore, the present study aimed to evaluate aids risk perception and its related f...

BACKGROUND Human papillomavirus (HPV) genotyping assays are becoming increasingly attractive for use in mass screening, as they offer a possibility to integrate HPV screening with HPV vaccine monitoring, thereby generating a synergy between the two main modes of cervical cancer prevention. The Genomica CLART HPV2 assay is a semi-automated PCR-based microarray assay detecting 35 high-risk and lo...

A genotyping study of 285 Hybrid Capture 2 low-risk probe cocktail-positive specimens showed cross-reactivity with several untargeted human papillomavirus genotypes. Cross-reactivity was often clinically beneficial due to the detection of untargeted low-risk genotypes. A total of 8.4% of positive results, usually weak, were due to cross-reactivity with high-risk genotypes. Establishment of a gr...

Because of their important roles in mediating the stabilization and expression of p53, we hypothesized that high-risk genotypes of polymorphisms in p53-related genes, including p53, p73, p14(ARF), MDM2 and MDM4, may be associated with an increased risk of second primary malignancy (SPM) after index squamous cell carcinoma of the head and neck (SCCHN). We analyzed data from a cohort of 1283 pati...

The Frequency of High-Risk and Low-Risk Human Papillomavirus Genotypes in Different Grades Cervical Lesions Shiraz, South-West Iran